ArticleJournal of virology2006
Humoral responses against coimmunized protein antigen but not against alphavirus-encoded antigens require alpha/beta interferon signaling.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
24 citing papers in PubMed, 42 citations in OpenAlex.
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- Viable mutations of mouse midnolin suppress B cell malignancies.The Journal of experimental medicine · 2024Article
- SLFN2 protection of tRNAs from stress-induced cleavage is essential for T cell-mediated immunity.Science (New York, N.Y.) · 2021Article
- Genetic and structural studies of RABL3 reveal an essential role in lymphoid development and function.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- LMBR1L regulates lymphopoiesis through Wnt/β-catenin signaling.Science (New York, N.Y.) · 2019Article
- A Link Between a Common Mutation in CFTR and Impaired Innate and Adaptive Viral Defense.The Journal of infectious diseases · 2017Article
- Real-time resolution of point mutations that cause phenovariance in mice.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
- Article
- RETRACTED: MAVS, cGAS, and endogenous retroviruses in T-independent B cell responses.Science (New York, N.Y.) · 2014Article
- An alphavirus-based adjuvant enhances serum and mucosal antibodies, T cells, and protective immunity to influenza virus in neonatal mice.Journal of virology · 2014Article
- The immunological profile of tumor-bearing animals determines the outcome of cancer immunotherapy.Oncoimmunology · 2013Article
- The adjuvant activity of alphavirus replicons is enhanced by incorporating the microbial molecule flagellin into the replicon.PloS one · 2013Article
- Virotherapy, gene transfer and immunostimulatory monoclonal antibodies.Oncoimmunology · 2012Article
- A forward genetic screen reveals roles for Nfkbid, Zeb1, and Ruvbl2 in humoral immunity.Proceedings of the National Academy of Sciences of the United States of America · 2012Article
- Human and rhesus plasmacytoid dendritic cell and B-cell responses to Toll-like receptor stimulation.Immunology · 2011Article
- IFN-α produced by human plasmacytoid dendritic cells enhances T cell-dependent naïve B cell differentiation.Journal of leukocyte biology · 2011Article
- Role of innate signalling pathways in the immunogenicity of alphaviral replicon-based vaccines.Virology journal · 2011Article
- A chimeric alphavirus replicon particle vaccine expressing the hemagglutinin and fusion proteins protects juvenile and infant rhesus macaques from measles.Journal of virology · 2010Article
- Type I interferon induction is correlated with attenuation of a South American eastern equine encephalitis virus strain in mice.Virology · 2009Article
- The contribution of type I interferon signaling to immunity induced by alphavirus replicon vaccines.Vaccine · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Viruses typically elicit potent adaptive immune responses, and live-virus-based vaccines are among the most efficient human vaccines known. The mechanisms by which viruses stimulate adaptive immune responses are not fully understood, but activation of innate immune signaling pathways in the early phase of the infection may be of importance. In addition to stimulating immune responses to viral antigens expressed in infected cells, viruses can also provide adjuvant signals to coimmunized protein antigens. Using recombinant Semliki Forest virus (rSFV)-based vaccines, we show that rSFV potently enhanced antibody responses against coimmunized protein antigens in the absence of other exogenously added adjuvants. Elicitation of antibody responses against both virus-encoded antigens and coimmunized protein antigens was independent of the signaling via Toll-like receptors (TLRs) previously implicated in antiviral responses. In contrast, the adjuvant effect of rSFV on coimmunized protein was completely abolished in mice lacking the alpha/beta interferon (IFN-alpha/beta) receptor (IFN-AR1), demonstrating that IFN-alpha/beta signaling was critical for mediating this effect. Antibody responses directed against virus-encoded antigens were intact in IFN-AR1(-/-) mice, suggesting that other signals are sufficient to drive immune responses against virally encoded antigens. These data provide a basis for the adjuvant effect of rSFV and show that different signals are required to stimulate antibody responses to virally encoded antigens and to antigens administered as purified protein vaccines, together with viral particles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.