ArticleJournal of virology2006
Vaccinia virus intermediate and late promoter elements are targeted by the TATA-binding protein.
Article in Journal of virology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 36 citations in OpenAlex.
- Birth of protein folds and functions in the virome.Nature · 2024Article
- Monkeypox virus genomic accordion strategies.Nature communications · 2024Article
- Injection site vaccinology of a recombinant vaccinia-based vector reveals diverse innate immune signatures.PLoS pathogens · 2021Article
- The African Swine Fever Virus Transcriptome.Journal of virology · 2020Article
- Analysis of a Marseillevirus Transcriptome Reveals Temporal Gene Expression Profile and Host Transcriptional Shift.Frontiers in microbiology · 2020Article
- Comparative in silico study of congocidine congeners as potential inhibitors of African swine fever virus.PloS one · 2019Article
- Article
- Identification of Vaccinia Virus Replisome and Transcriptome Proteins by Isolation of Proteins on Nascent DNA Coupled with Mass Spectrometry.Journal of virology · 2017Article
- Promoter Motifs in NCLDVs: An Evolutionary Perspective.Viruses · 2017Review
- Human antibody responses to the polyclonal Dryvax vaccine for smallpox prevention can be distinguished from responses to the monoclonal replacement vaccine ACAM2000.Clinical and vaccine immunology : CVI · 2014Article
- Cascade regulation of vaccinia virus gene expression is modulated by multistage promoters.Virology · 2013Article
- Barrier to autointegration factor (BAF) inhibits vaccinia virus intermediate transcription in the absence of the viral B1 kinase.Virology · 2013Article
- Human genome-wide RNAi screen reveals a role for nuclear pore proteins in poxvirus morphogenesis.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- Correlates between host and viral transcriptional program associated with different oncolytic vaccinia virus isolates.Human gene therapy methods · 2012Article
- Pervasive initiation and 3'-end formation of poxvirus postreplicative RNAs.The Journal of biological chemistry · 2012Article
- Expression profiling of the intermediate and late stages of poxvirus replication.Journal of virology · 2011Article
- Comparative whole genome sequence analysis of wild-type and cidofovir-resistant monkeypoxvirus.Virology journal · 2010Article
- Vaccinia virus E2L null mutants exhibit a major reduction in extracellular virion formation and virus spread.Journal of virology · 2008Article
- Expansion of poxvirus RNA polymerase subunits sharing homology with corresponding subunits of RNA polymerase II.Virus genes · 2008Article
- Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Vaccinia virus replicates in the cytoplasm of the host cell and encodes its own RNA polymerase and transcription factors. The proteins that target the poxvirus RNA polymerase to intermediate- and late-class promoters have not been identified. In this study, representatives of the intermediate and late promoters were characterized at the nucleotide level to identify essential motifs. Both intermediate and late viral promoters are shown to have an essential element suggestive of TATA boxes, which are potential targets for the TATA-binding protein (TBP). Several approaches were used to test for TBP requirement in vaccinia virus transcription, including overexpression of TBP, expression of a dominant negative mutant of TBP, RNA interference, and expression of adenovirus E1A protein, which inactivates TBP. In each case, the results support an essential role for TBP in vaccinia virus intermediate- and late-gene transcription. These findings indicate that poxviruses have integrated TBP as a central feature into an otherwise heterologous transcription system. A model for transcriptional switching, in which both intermediate and late promoter elements are targeted by TBP that recruits viral transcription factors to assemble a functional complex on their cognate promoters and a dysfunctional, repressed complex on the other class, is proposed.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.