ArticleGenome biology2006
Evolution of candidate transcriptional regulatory motifs since the human-chimpanzee divergence.
Article in Genome biology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- Dystrophin-Glycoprotein Complex Behavior in Sternocleidomastoid Muscle of High- and Low-Ranking Baboons: A Possible Phylogenetic Arrangement.Journal of functional morphology and kinesiology · 2022Article
- Genome-wide identification and characterization of fixed human-specific regulatory regions.American journal of human genetics · 2014Article
- Conserved expression of lincRNA during human and macaque prefrontal cortex development and maturation.RNA (New York, N.Y.) · 2014Article
- Reconstructing phylogenies and phenotypes: a molecular view of human evolution.Journal of anatomy · 2008Review
- On the relation between promoter divergence and gene expression evolution.Molecular systems biology · 2008Article
- Regulatory conservation of protein coding and microRNA genes in vertebrates: lessons from the opossum genome.Genome biology · 2007Article
- What makes us human: revisiting an age-old question in the genomic era.Journal of biomedical discovery and collaboration · 2006Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
backgroundDespite the recent completion of the chimpanzee genome project, few functionally significant sequence differences between humans and chimpanzees have thus far been identified. Alteration in transcriptional regulatory mechanisms represents an important platform for evolutionary change, suggesting that a significant proportion of functional human-chimpanzee sequence differences may affect regulatory elements.
resultsTo explore this hypothesis, we performed genome-wide identification of conserved candidate transcription-factor binding sites that have evolved since the divergence of humans and chimpanzees. Analysis of candidate transcription-factor binding sites conserved between mouse and chimpanzee yet absent in human indicated that loss of candidate transcription-factor binding sites in the human lineage was not random but instead correlated with the biologic functions of associated genes.
conclusionOur data support the notion that changes in transcriptional regulation have contributed to the recent evolution of humans. Moreover, genes associated with mutated candidate transcription-factor binding sites highlight potential pathways underlying human-chimpanzee divergence.
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