ArticleThe Journal of cell biology1991
Lateral diffusion of membrane-spanning and glycosylphosphatidylinositol-linked proteins: toward establishing rules governing the lateral mobility of membrane proteins.
Article in The Journal of cell biology, 1991. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 144 citations in OpenAlex.
- (Patho)Physiology of Glycosylphosphatidylinositol-Anchored Proteins II: Intercellular Transfer of Matter (Inheritance?) That Matters.Biomolecules · 2023Review
- Exosome secretion kinetics are controlled by temperature.Biophysical journal · 2023Article
- The Glycosylphosphatidylinositol Anchor: A Linchpin for Cell Surface Versatility of Trypanosomatids.Frontiers in cell and developmental biology · 2021Review
- Lateral diffusion of CD14 and TLR2 in macrophage plasma membrane assessed by raster image correlation spectroscopy and single particle tracking.Scientific reports · 2020Article
- Nanoscale analysis reveals no domain formation of glycosylphosphatidylinositol-anchored protein SAG1 in the plasma membrane of living Toxoplasma gondii.Histochemistry and cell biology · 2019Article
- Actin filaments partition primary cilia membranes into distinct fluid corrals.The Journal of cell biology · 2018Article
- Using Scaffold Liposomes to Reconstitute Lipid-proximal Protein-protein Interactions In Vitro.Journal of visualized experiments : JoVE · 2017Article
- Spatiotemporal analysis with a genetically encoded fluorescent RNA probe reveals TERRA function around telomeres.Scientific reports · 2016Article
- Dynamic pre-BCR homodimers fine-tune autonomous survival signals in B cell precursor acute lymphoblastic leukemia.Science signaling · 2016Article
- N-glycosylation enables high lateral mobility of GPI-anchored proteins at a molecular crowding threshold.Nature communications · 2016Article
- GPI-anchored protein organization and dynamics at the cell surface.Journal of lipid research · 2016Review
- There Is No Simple Model of the Plasma Membrane Organization.Frontiers in cell and developmental biology · 2016Review
- The molecular size of the extra-membrane domain influences the diffusion of the GPI-anchored VSG on the trypanosome plasma membrane.Scientific reports · 2015Article
- GPI-anchored proteins do not reside in ordered domains in the live cell plasma membrane.Nature communications · 2015Article
- Lateral dynamics of proteins with polybasic domain on anionic membranes: a dynamic Monte-Carlo study.Biophysical journal · 2011Article
- Essential role for the CRAC activation domain in store-dependent oligomerization of STIM1.Molecular biology of the cell · 2010Article
- Getting a grip on Thy-1 signaling.Biochimica et biophysica acta · 2009Review
- C3b deposition on human erythrocytes induces the formation of a membrane skeleton-linked protein complex.The Journal of clinical investigation · 2009Article
- Expression of excess receptors and negative feedback control of signal pathways are required for rapid activation and prompt cessation of signal transduction.Cell communication and signaling : CCS · 2009Article
- Clathrin-independent endocytosis of ErbB2 in geldanamycin-treated human breast cancer cells.Journal of cell science · 2008Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
In the plasma membrane of animal cells, many membrane-spanning proteins exhibit lower lateral mobilities than glycosylphosphatidylinositol (GPI)-linked proteins. To determine if the GPI linkage was a major determinant of the high lateral mobility of these proteins, we measured the lateral diffusion of chimeric membrane proteins composed of normally transmembrane proteins that were converted to GPI-linked proteins, or GPI-linked proteins that were converted to membrane-spanning proteins. These studies indicate that GPI linkage contributes only marginally (approximately twofold) to the higher mobility of several GPI-linked proteins. The major determinant of the high mobility of these proteins resides instead in the extracellular domain. We propose that lack of interaction of the extracellular domain of this protein class with other cell surface components allows diffusion that is constrained only by the diffusion of the membrane anchor. In contrast, cell surface interactions of the ectodomain of membrane-spanning proteins exemplified by the vesicular stomatitis virus G glycoprotein reduces their lateral diffusion coefficients by nearly 10-fold with respect to many GPI-linked proteins.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.