ArticleYonsei medical journal2006
A 20-year-old woman with Hashimoto's thyroiditis and Evans' syndrome.
Article in Yonsei medical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers, 1 of them a synthesis that pooled it.
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Who cites it
5 citing papers in PubMed, 1 synthesis or guideline pooled it, 11 citations in OpenAlex.
- Audiovestibular Dysfunction in Patients with Hashimoto's Disease: A Systematic Review.International journal of molecular sciences · 2025Pooled it
- Hashimoto's thyroiditis associated Evans syndrome: A rare case report on the clustered autoimmune disease triad.Indian journal of endocrinology and metabolism · 2013Article
- Evans syndrome following long-standing Hashimoto's thyroiditis and successful treatment with rituximab.The Korean journal of hematology · 2011Article
- Thyroid-associated autoimmune coagulation disorders.Journal of thrombosis and thrombolysis · 2010Review
- Possible association between thyroid autoimmunity and Menière's disease.Clinical and experimental immunology · 2008Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Here we report the case of a 20-year-old female patient previously diagnosed with Hashimoto's thyroiditis and overt hypothyroidism, and who had been taking synthetic thyroxine (100 microg/day) for eight months. She experienced intermittent dizziness and generalized weakness, and was diagnosed as having severe autoimmune hemolytic anemia (AIHA). We prescribed prednisolone treatment and continued synthetic thyroxine administration. Two years and five months later, she developed idiopathic thrombocytopenic purpura (ITP) and was diagnosed with Evans' syndrome. Thereafter, laparoscopic splenectomy was performed because her autoimmune hemolytic anemia was refractory and dependent on steroid therapy. The HLA genotypes of the patient were HLA-A*020101/A* 2602, HLA-B*270502/B*5401, HLA-Cw*0102/Cw*020202, HLA-DRB1*0404/DRB1*0405, and HLA-DQB1*0302/DQ B1*0401. Hashimoto's thyroiditis is often associated with other nonendocrine autoimmune diseases, and antithyroid antibodies are frequently observed in Evans' syndrome (coexistence of AIHA and ITP). However, there is no report of Evans' syndrome developing in patients with overt hypothyroidism and Hashimoto's thyroiditis. This case suggests that three autoimmune diseases (AIHA, ITP, and Hashimoto's thyroiditis) might share a common immunogenetic pathway in pathogenesis.
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