ReviewJournal of mammary gland biology and neoplasia2005
Myoepithelial cells in the control of mammary development and tumorigenesis: data from genetically modified mice.
Review in Journal of mammary gland biology and neoplasia, 2005. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 35 citations in OpenAlex.
- Gap junction communication regulates luminal-myoepithelial crosstalk and cell differentiation in a bilayered human mammary epithelial cell model.Biology methods & protocols · 2026Article
- Article
- Origin and Lineage Plasticity of Endogenous Lacrimal Gland Epithelial Stem/Progenitor Cells.iScience · 2020Article
- SFRP1 in Skin Tumor Initiation and Cancer Stem Cell Regulation with Potential Implications in Epithelial Cancers.Stem cell reports · 2020Article
- TRAF6 maintains mammary stem cells and promotes pregnancy-induced mammary epithelial cell expansion.Communications biology · 2019Article
- Myoepithelial cells are a dynamic barrier to epithelial dissemination.The Journal of cell biology · 2018Article
- The V-ATPase a2 isoform controls mammary gland development through Notch and TGF-β signaling.Cell death & disease · 2016Article
- Comparative Multifractal Analysis of Dynamic Infrared Thermograms and X-Ray Mammograms Enlightens Changes in the Environment of Malignant Tumors.Frontiers in physiology · 2016Article
- Myoepithelial Cells: Their Origin and Function in Lacrimal Gland Morphogenesis, Homeostasis, and Repair.Current molecular biology reports · 2015Article
- Cellular foundations of mammary tubulogenesis.Seminars in cell & developmental biology · 2014Review
- Biocompatible tissue scaffold compliance promotes salivary gland morphogenesis and differentiation.Tissue engineering. Part A · 2014Article
- A post-GWAS replication study confirming the PTK2 gene associated with milk production traits in Chinese Holstein.PloS one · 2013Article
- Replacement of E-cadherin by N-cadherin in the mammary gland leads to fibrocystic changes and tumor formation.Breast cancer research : BCR · 2011Article
- Altered differentiation and paracrine stimulation of mammary epithelial cell proliferation by conditionally activated Smoothened.Developmental biology · 2011Article
- Murine amniotic fluid stem cells contribute mesenchymal but not epithelial components to reconstituted mammary ducts.Stem cell research & therapy · 2010Article
- Breast carcinomatous tumoral emboli can result from encircling lymphovasculogenesis rather than lymphovascular invasion.Oncotarget · 2010Article
- Ovarian hormones are not required for PRL-induced mammary tumorigenesis, but estrogen enhances neoplastic processes.The Journal of endocrinology · 2009Article
- Progestin-regulated luminal cell and myoepithelial cell-specific responses in mammary organoid culture.Endocrinology · 2008Article
- The MAPK(ERK-1,2) pathway integrates distinct and antagonistic signals from TGFalpha and FGF7 in morphogenesis of mouse mammary epithelium.Developmental biology · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Until recently, myoepithelial cells-the second major cell population in the mammary epithelium-were not considered to play an important role in the morphogenetic events during gland development. Mouse mutants with changes in the gene expression pattern characteristic of the basal myoepithelial cell layer have been generated and used to show that these cells influence the proliferation, survival and differentiation of luminal cells, modulate stromal-epithelial interactions and actively participate in mammary morphogenesis. Various cellular and molecular mechanisms may underlie the observed phenotypes. These include an unbalanced expression of matrix degrading metalloproteinases (MMPs) and their inhibitors, leading to changes in the composition and organization of the (extracellular matrix) ECM, the production of soluble growth factors affecting stromal and epithelial cell growth and differentiation and direct signaling through cell-cell contacts between the myoepithelial and luminal cell layers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.