ArticleImmunogenetics2006
Generation and maintenance of diversity in the cattle MHC class I region.
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed.
- Article
- Article
- Improved Prediction of Bovine Leucocyte Antigens (BoLA) Presented Ligands by Use of Mass-Spectrometry-Determined Ligand and in Vitro Binding Data.Journal of proteome research · 2018Article
- Genome-wide scan for runs of homozygosity identifies potential candidate genes associated with local adaptation in Valle del Belice sheep.Genetics, selection, evolution : GSE · 2017Article
- Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing.Immunogenetics · 2016Article
- Article
- A comprehensive mapping of the structure and gene organisation in the sheep MHC class I region.BMC genomics · 2015Article
- The assembly and characterisation of two structurally distinct cattle MHC class I haplotypes point to the mechanisms driving diversity.Immunogenetics · 2015Article
- Pathogenicity of Bovine Neonatal Pancytopenia-associated vaccine-induced alloantibodies correlates with Major Histocompatibility Complex class I expression.Scientific reports · 2015Article
- Characterisation of major histocompatibility complex class I genes at the fetal-maternal interface of marsupials.Immunogenetics · 2015Article
- Bovine Neonatal Pancytopenia is a heritable trait of the dam rather than the calf and correlates with the magnitude of vaccine induced maternal alloantibodies not the MHC haplotype.Veterinary research · 2014Article
- Characterization of binding specificities of bovine leucocyte class I molecules: impacts for rational epitope discovery.Immunogenetics · 2014Article
- Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K.Immunogenetics · 2013Article
- Constraints on haplotype structure and variable gene frequencies suggest a functional hierarchy within cattle MHC class I.Immunogenetics · 2012Article
- Cattle MHC nomenclature: is it possible to assign sequences to discrete class I genes?Immunogenetics · 2012Article
- Extensive polymorphism and evidence of immune selection in a highly dominant antigen recognized by bovine CD8 T cells specific for Theileria annulata.Infection and immunity · 2011Article
- Genome-wide footprints of pig domestication and selection revealed through massive parallel sequencing of pooled DNA.PloS one · 2011Article
- Induction of a cross-reactive CD8(+) T cell response following foot-and-mouth disease virus vaccination.Journal of virology · 2010Article
- MHC class I bound to an immunodominant Theileria parva epitope demonstrates unconventional presentation to T cell receptors.PLoS pathogens · 2010Article
- MHC gene copy number variation in Tasmanian devils: implications for the spread of a contagious cancer.Proceedings. Biological sciences · 2010Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Major histocompatibility complex (MHC) class I genes play a crucial role in the immune defence against intracellular pathogens. An important evolutionary strategy is to generate and maintain a high level of diversity in these genes. Humans express three highly polymorphic classical MHC class I genes (HLA-A, HLA-B and HLA-C). In contrast, some species, for example rat and rhesus macaque, maintain diversity by generation of haplotypes that vary considerably with regard to the number and combination of transcribed genes. Cattle appear to use both strategies. We show that various combinations of six apparently classical genes, three of which are highly polymorphic, are transcribed on different haplotypes. Although additional sequences were identified in both cDNA and gDNA, it was not possible to assign them to any of these defined genes. Most were highly divergent or were non-classical class I genes. Thus, we found little evidence for frequent duplication and deletion of classical class I genes as reported in some other species. However, the maintenance of class I diversity in cattle may involve limited gene shuffling and deletion, possibly as a result of unequal crossing-over within the class I region.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.