Evidence map›Paper›PMID 16807730›Full record

ReviewEuropean journal of pediatrics2006

Population clinical pharmacology of children: general principles.

Brian J Anderson, Karel Allegaert, Nicholas H G Holford

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in European journal of pediatrics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01462500 (Pharmacokinetics of Miltefosine in Children and Adults), which is not on this map. Cited by 49 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01462500 phase4completednot on this mapstarted 2011, after this paper: background citation

Pharmacokinetics of Miltefosine in Children and Adults: Implications for the Treatment of Cutaneous Leishmaniasis in Colombia.

TypeinterventionalSponsorCentro Internacional de Entrenamiento e Investigaciones MédicasRan2011 to 2015Enrolled60ConditionsCutaneous LeishmaniasisArmsMiltefosine
3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  14. Use of Antibiotics in Preterm Newborns.Antibiotics (Basel, Switzerland) · 2022
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Brian J AndersonDepartment of Anaesthesiology, University of Auckland, Auckland, New Zealand. briana@adhb.govt.nz
Karel Allegaert
Nicholas H G Holford

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPopulation modelling using mixed-effects models provides a means to study variability in drug responses among individuals representative of those for whom the drug will be used clinically. DISCUSSION: The advantages of these models in paediatric studies are that they can be used to analyse sparse data, sampling times are not crucial and can be fitted around clinical procedures and individuals with missing data may still be included in the analysis. The introduction of explanatory covariates explains the predictable part of the between-individual variability. Simulations using parameter estimates and their variability can be used to investigate large numbers of children--many more than is possible in studies dealing with real children--for a fraction of the cost, which is an advantage when developing clinical trials. Paediatric population modelling has expanded greatly in the past decade and is now a routine procedure during the development and investigation of drugs. Children have benefitted and will continue to benefit from this approach.

Indexed as

Models, BiologicalPediatricsPharmacokineticsPharmacology, ClinicalChildComputer SimulationHumans

Identifiers

PMID16807730

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.