ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
Variability of motor neuron spike timing maintains and shapes contractions of the accessory radula closer muscle of Aplysia.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed.
- Visuomotor control in mice and primates.Neuroscience and biobehavioral reviews · 2021Review
- Increasing Muscle Speed Drives Changes in the Neuromuscular Transform of Motor Commands during Postnatal Development in Songbirds.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2020Article
- Precise timing is ubiquitous, consistent, and coordinated across a comprehensive, spike-resolved flight motor program.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Detection of Activation Sequences in Spiking-Bursting Neurons by means of the Recognition of Intraburst Neural Signatures.Scientific reports · 2018Article
- Millisecond Spike Timing Codes for Motor Control.Trends in neurosciences · 2018Article
- Millisecond-scale motor encoding in a cortical vocal area.PLoS biology · 2014Article
- The neuromuscular transform of the lobster cardiac system explains the opposing effects of a neuromodulator on muscle output.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Motor circuit-specific burst patterns drive different muscle and behavior patterns.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Review
- Single synapse information coding in intraburst spike patterns of central pattern generator motor neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
- Relating neuronal to behavioral performance: variability of optomotor responses in the blowfly.PloS one · 2011Article
- History-dependent excitability as a single-cell substrate of transient memory for information discrimination.PloS one · 2010Article
- Axonal sodium channel distribution shapes the depolarized action potential threshold of dentate granule neurons.Hippocampus · 2010Article
- Noise in the nervous system.Nature reviews. Neuroscience · 2008Review
- Functional penetration of variability of motor neuron spike timing through a modulated neuromuscular system.Neurocomputing · 2007Article
- Cycle-to-cycle variability as an optimal behavioral strategy.Neurocomputing · 2006Article
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2 authors.
Funding
Abstract
The accessory radula closer (ARC) muscle of Aplysia has long been studied as a typical "slow" muscle, one that would be assumed to respond only to the overall, integrated spike rate of its motor neurons, B15 and B16. The precise timing of the individual spikes should not much matter. However, but real B15 and B16 spike patterns recorded in vivo show great variability that extends down to the timing of individual spikes. By replaying these real as well as artificially constructed spike patterns into ARC muscles in vitro, we examined the consequences of this spike-level variability for contraction. Replaying the same pattern several times reproduces precisely the same contraction shape: the B15/B16-ARC neuromuscular transform is deterministic. However, varying the timing of the spikes produces very different contraction shapes and amplitudes. The transform in fact operates at an interface between "fast" and "slow" regimens. It is fast enough that the timing of individual spikes greatly influences the detailed contraction shape. At the same time, slow integration of the spike pattern through the nonlinear transform allows the variable spike timing to determine also the overall contraction amplitude. Indeed, the variability appears to be necessary to maintain the contraction amplitude at a robust level. This phenomenon is tuned by neuromodulators that tune the speed and nonlinearity of the transform. Thus, the variable timing of individual spikes does matter, in at least two, functionally significant ways, in this "slow" neuromuscular system.
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