ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2006
GABA transporters regulate a standing GABAC receptor-mediated current at a retinal presynaptic terminal.
Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- Article
- GABA receptors mediate adaptation and sensitization processes in mouse retinal ganglion cells.Cognitive neurodynamics · 2024Article
- Diverse inhibitory and excitatory mechanisms shape temporal tuning in transient OFF α ganglion cells in the rabbit retina.The Journal of physiology · 2018Article
- Dopamine-Dependent Sensitization of Rod Bipolar Cells by GABA Is Conveyed through Wide-Field Amacrine Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2018Article
- Neurally Released GABA Acts via GABAFrontiers in physiology · 2018Article
- The Contribution of L-Type CaFrontiers in molecular neuroscience · 2017Article
- Retinoschisin Facilitates the Function of L-Type Voltage-Gated Calcium Channels.Frontiers in cellular neuroscience · 2017Article
- Extrasynaptic release of GABA and dopamine by retinal dopaminergic neurons.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2015Review
- Disruption of a neural microcircuit in the rod pathway of the mammalian retina by diabetes mellitus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- GABAergic neurotransmission and retinal ganglion cell function.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Calcium spike-mediated digital signaling increases glutamate output at the visual threshold of retinal bipolar cells.Journal of neurophysiology · 2015Article
- Building blocks of temporal filters in retinal synapses.PLoS biology · 2014Article
- An intracellular redox sensor for reactive oxygen species at the M3-M4 linker of GABAA ρ1 receptors.British journal of pharmacology · 2014Article
- Ionotropic GABA Receptors and Distal Retinal ON and OFF Responses.Scientifica · 2014Review
- The impact of tonic GABAA receptor-mediated inhibition on neuronal excitability varies across brain region and cell type.Frontiers in neural circuits · 2014Review
- Nitric oxide potentiation of the homomeric ρ1 GABA(C) receptor function.British journal of pharmacology · 2012Article
- Paired-pulse plasticity in the strength and latency of light-evoked lateral inhibition to retinal bipolar cell terminals.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- The mode of retinal presynaptic inhibition switches with light intensity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2012Article
- Rod vision is controlled by dopamine-dependent sensitization of rod bipolar cells by GABA.Neuron · 2011Article
- Allosteric modulation of retinal GABA receptors by ascorbic acid.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2011Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
At the axon terminal of goldfish retinal bipolar cells, GABA(C) receptors have been shown to mediate inhibitory reciprocal synaptic currents. Here, we demonstrate a novel standing GABAergic current mediated exclusively by GABA(C) receptors. Selective inhibition of GAT-1 GABA transporters on amacrine cells increases this tonic current and reveals a specific functional coupling between GAT-1 transporters and GABA(C) receptors. We propose that this GABA(C) receptor-mediated standing current serves to regulate synaptic gain by shunting depolarizing potentials that can produce Ca2+-dependent action potentials at the bipolar cell terminal. Furthermore, we find that the amount of GABA(C) receptor-mediated reciprocal feedback between bipolar cell terminals and amacrine cells is greatly increased when GAT-1 transporters are specifically blocked by NO-711 (1-[2-[[(diphenylmethylene)imino]oxy]ethyl]-1,2,5,6-tetrahydro-3-pyridinecarboxylic acid hydrochloride). The involvement of GAT-1 transporters in regulating this standing (or tonic) GABA(C) current implicates them in a novel role as major determinants of presynaptic excitability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.