ArticleNucleic acids research2006
Genes invoked in the ovarian transition to menopause.
Article in Nucleic acids research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 29 citations in OpenAlex.
- Menopause mysteries: the exosome-inflammation connection.Journal of ovarian research · 2025Review
- Cystathionine β-synthase is required for oocyte quality by ensuring proper meiotic spindle assembly.Cell proliferation · 2022Article
- Aberrant Transferrin and Ferritin Upregulation Elicits Iron Accumulation and Oxidative Inflammaging Causing Ferroptosis and Undermines Estradiol Biosynthesis in Aging Rat Ovaries by Upregulating NF-Κb-Activated Inducible Nitric Oxide Synthase: First Demonstration of an Intricate Mechanism.International journal of molecular sciences · 2022Article
- Sex-related differences in the response of anti-platelet drug therapies targeting purinergic signaling pathways in sepsis.Frontiers in immunology · 2022Article
- Temporal transcriptomic landscape of postnatal mouse ovaries reveals dynamic gene signatures associated with ovarian aging.Human molecular genetics · 2021Article
- Direct Imaging of Lipid Metabolic Changes inFrontiers in aging · 2021Article
- Dynamic Changes of DNA Methylation and Transcriptome Expression in Porcine Ovaries during Aging.BioMed research international · 2019Article
- Ovarian transcriptome associated with reproductive senescence in the long-living Ames dwarf mice.Molecular and cellular endocrinology · 2017Article
- Coagulansin-A has beneficial effects on the development of bovine embryos in vitro via HSP70 induction.Bioscience reports · 2016Article
- Estrogen deprivation does not affect vascular heat shock response in female rats: a comparison with oxidative stress markers.Molecular and cellular biochemistry · 2015Article
- Local estrogen metabolism in epithelial ovarian cancer suggests novel targets for therapy.The Journal of steroid biochemistry and molecular biology · 2015Article
- Age-Specific Gene Expression Profiles of Rhesus Monkey Ovaries Detected by Microarray Analysis.BioMed research international · 2015Article
- Purinergic signalling in the reproductive system in health and disease.Purinergic signalling · 2014Review
- Purinergic signalling in endocrine organs.Purinergic signalling · 2014Review
- The transcription factor GATA4 is required for follicular development and normal ovarian function.Developmental biology · 2013Article
- Article
- Effects of aging and calorie restriction on the global gene expression profiles of mouse testis and ovary.BMC biology · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Menopause and the associated declines in ovarian function are major health issues for women. Despite the widespread health impact of this process, the molecular mechanisms underlying the aging-specific decline in ovarian function are almost completely unknown. To provide the first gene-protein analysis of the ovarian transition to menopause, we have established and contrasted RNA gene expression profiles and protein localization and content patterns in healthy young and perimenopausal mouse ovaries. We report a clear distinction in specific mRNA and protein levels that are noted prior to molecular evidence of steroidogenic failure. In this model, ovarian reproductive aging displays similarities with chronic inflammation and increased sensitivity to environmental cues. Overall, our results indicate the presence of mouse climacteric genes that are likely to be major players in aging-dependent changes in ovarian function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.