ArticleWorld journal of gastroenterology2006
Functional studies of a novel oncogene TGM3 in human esophageal squamous cell carcinoma.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
7 citing papers in PubMed, 17 citations in OpenAlex.
- Positional cloning and next-generation sequencing identified a TGM6 mutation in a large Chinese pedigree with acute myeloid leukaemia.European journal of human genetics : EJHG · 2015Article
- TGM3, a candidate tumor suppressor gene, contributes to human head and neck cancer.Molecular cancer · 2013Article
- Combination of meta-analysis and graph clustering to identify prognostic markers of ESCC.Genetics and molecular biology · 2012Article
- Quantitative proteomics using formalin-fixed paraffin-embedded tissues of oral squamous cell carcinoma.Cancer science · 2009Article
- Validation of tissue microarray technology in squamous cell carcinoma of the esophagus.Virchows Archiv : an international journal of pathology · 2008Article
- Examination of oral cancer biomarkers by tissue microarray analysis.Archives of otolaryngology--head & neck surgery · 2008Article
- Methylation of TGM-3 Promoter and Its Association with Oral Squamous Cell Carcinoma (OSCC).Avicenna journal of medical biotechnologyArticle
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimTo investigate the role of transglutaminase 3 (TGM3) gene in human esophageal squamous cell carcinoma (ESCC), and analyze its relationship with clinicopathological parameters.
methodsGene expression of TGM3 in fresh esophageal cancer tissues and their corresponding normal mucosas was detected immunohistochemically (IHC) by means of tissue microarray (TMA). Its correlation with clinical characteristics was evaluated and analyzed by univariate analysis. All statistical analyses were performed by SPSS version 10.0.
resultsExpression rate of TGM3 was reduced to 81.8% in ESCC. Expression of TGM3 was significantly inversely correlated with histological grade of esophageal carcinoma (in grade I, II and III tumors, the reduced expression was 4/7, 57/71, and 20/21, respectively, P < 0.05), whereas it had no obvious correlations with lymph node metastasis and depth of invasion.
conclusionReduced expression of TGM3 may play an important role in esophageal carcinogenesis.
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