ArticleWorld journal of gastroenterology2006
Increased hepatic expression of insulin-like growth factor-I receptor in chronic hepatitis C.
Article in World journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 28 citations in OpenAlex.
- Markers of liver regeneration-the role of growth factors and cytokines: a systematic review.BMC surgery · 2020Pooled it
- Chronic hepatitis C treatment outcomes in low- and middle-income countries: a systematic review and meta-analysis.Bulletin of the World Health Organization · 2012Pooled it
- Metabolic Health and Disease: A Role of Osteokines?Calcified tissue international · 2023Review
- The GH/IGF-1 Axis Is Associated With Intrahepatic Lipid Content and Hepatocellular Damage in Overweight/Obesity.The Journal of clinical endocrinology and metabolism · 2022Article
- Expression of IGF-1 receptor and GH receptor in hepatic tissue of patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis.Growth hormone & IGF research : official journal of the Growth Hormone Research Society and the International IGF Research Society · 2022Article
- Expression of insulin-like growth factor I and its receptor in the liver of children with biopsy-proven NAFLD.PloS one · 2018Article
- The Role of Growth Hormone and Insulin-Like Growth Factor-I in the Liver.International journal of molecular sciences · 2017Review
- Insulin-Like Growth Factor-1 Deficiency and Cirrhosis Establishment.Journal of clinical medicine research · 2017Review
- Isoflurane anesthesia induces liver injury by regulating the expression of insulin-like growth factor 1.Experimental and therapeutic medicine · 2017Article
- The Association Between IGF-1 Levels and the Histologic Severity of Nonalcoholic Fatty Liver Disease.Clinical and translational gastroenterology · 2017Article
- Insulin-like growth factor-related components and the risk of liver cancer in a nested case-control study.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Insulin-like growth factor-1 mRNA isoforms and insulin-like growth factor-1 receptor mRNA expression in chronic hepatitis C.World journal of gastroenterology · 2015Article
- The GH-IGF-SST system in hepatocellular carcinoma: biological and molecular pathogenetic mechanisms and therapeutic targets.Infectious agents and cancer · 2014Review
- The identification of stem cells in human liver diseases and hepatocellular carcinoma.Experimental and molecular pathology · 2010Article
- Growth hormone, IGF-I and insulin and their abuse in sport.British journal of pharmacology · 2008Review
- The insulin-like growth factor axis and risk of liver disease in hepatitis C virus/HIV-co-infected women.AIDS (London, England) · 2008Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimAlthough increased insulin-like growth factor-I receptor (IGF-IR) gene expression has been reported in hepatocellular carcinoma, studies assessing IGF-IR in chronic hepatitis C (CHC) and cirrhosis are scarce. We therefore aimed to evaluate IGF-IR and IGF-I mRNA expression in liver from patient with CHC.
methodsIGF-IR and IGF-I mRNA content were determined by semi-quantitative RT-PCR and IGF-IR protein expression was determined by immunohisto-chemistry in hepatic tissue obtained from patients with CHC before (34 patients) and after (10 patients) therapy with interferon-alpha and ribavirin.
resultsAn increase of IGF-IR mRNA content was observed in hepatic tissue obtained from all CHC patients as well as from 6 cadaveric liver donors following orthopic transplantation (an attempt to evaluate normal livers) in comparison to normal liver, while no relevant modifications were detected in IGF-I mRNA content. The immunohistochemical results showed that the raise in IGF-IR mRNA content was related both to ductular reaction and to increased IGF-IR expression in hepatocytes. A decrease in IGF-IR mRNA content was observed in patients who achieved sustained virological response after therapy, suggesting an improvement in hepatic damage.
conclusionThe up-regulation of IGF-IR expression in hepatocytes of patients with CHC could constitute an attempt to stimulate hepatocyte regeneration. Considering that liver is the organ with the highest levels of IGF-I, our finding of increased IGF-IR expression after both acute and chronic hepatic damage highlights the need for additional studies to elucidate the role of IGF-I in liver regeneration.
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