ArticleCurrent genetics2006
A secondary metabolite biosynthesis cluster in Trichoderma virens: evidence from analysis of genes underexpressed in a mutant defective in morphogenesis and antibiotic production.
Article in Current genetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 63 citations in OpenAlex.
- Fungal Hydrophobins: Taxonomic Distribution, Functional Roles, Physicochemical Properties, and Biotechnological Applications.Journal of fungi (Basel, Switzerland) · 2026Review
- Is heptelidic (koningic) acid a microbial hormone that regulates secondary metabolism in the biocontrol fungus Trichoderma virens?Current genetics · 2025Article
- Trichoderma species from plant and soil: An excellent resource for biosynthesis of terpenoids with versatile bioactivities.Journal of advanced research · 2023Review
- Review
- Editorial: Designing Bio-Formulations Based on Organic Amendments, Beneficial Microbes and Their Metabolites.Frontiers in microbiology · 2021Article
- Evaluation of Antioxidant, Antimicrobial and Tyrosinase Inhibitory Activities of Extracts fromAntibiotics (Basel, Switzerland) · 2020Article
- Whole Genome Sequencing Reveals Major Deletions in the Genome of M7, a Gamma Ray-Induced Mutant ofFrontiers in microbiology · 2020Article
- Regulation of conidiation and antagonistic properties of the soil-borne plant beneficial fungus Trichoderma virens by a novel proline-, glycine-, tyrosine-rich protein and a GPI-anchored cell wall protein.Current genetics · 2019Article
- A dedicated glyceraldehyde-3-phosphate dehydrogenase is involved in the biosynthesis of volatile sesquiterpenes in Trichoderma virens-evidence for the role of a fungal GAPDH in secondary metabolism.Current genetics · 2019Article
- A Novel Seed-Dressing Formulation Based on an Improved Mutant Strain ofFrontiers in microbiology · 2019Article
- Biosynthetic pathway for furanosteroid demethoxyviridin and identification of an unusual pregnane side-chain cleavage.Nature communications · 2018Article
- Histone acetyltransferase TGF-1 regulates Trichoderma atroviride secondary metabolism and mycoparasitism.PloS one · 2018Article
- Comprehensive curation and analysis of fungal biosynthetic gene clusters of published natural products.Fungal genetics and biology : FG & B · 2016Article
- The evolutionary imprint of domestication on genome variation and function of the filamentous fungus Aspergillus oryzae.Current biology : CB · 2012Article
- Trichoderma: the genomics of opportunistic success.Nature reviews. Microbiology · 2011Review
- Identification of loci and functional characterization of trichothecene biosynthesis genes in filamentous fungi of the genus Trichoderma.Applied and environmental microbiology · 2011Article
- Regulation of morphogenesis and biocontrol properties in Trichoderma virens by a VELVET protein, Vel1.Applied and environmental microbiology · 2010Article
- Antibiosis of Trichoderma spp strains native to northeastern Mexico against the pathogenic fungus Macrophomina phaseolina.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology]Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A transcriptional comparison of wild type and a secondary metabolite deficient Trichoderma virens mutant resulted in the identification of six genes similar to those involved in secondary metabolism in other fungi, including four cytochrome P450 genes, one O-methyl transferase and one terpene cylase. Four of the genes (three cytochrome P450s and the cyclase) are located as a cluster. Transcript levels of three of the P450 genes, the O-methyl transferase and the terpene cyclase were measured. These genes are underexpressed in the mutant, which lacks the major secondary metabolites produced by this strain, viridin and viridiol. Expression levels of clones from the differential library with similarity to fungal trehalose synthase and a hydrophobin were also underexpressed in the mutant, while a heat shock protein hsp98 homolog was not. Based on the gene expression pattern and associated secondary metabolite profile, along with similarity to other secondary metabolism pathways in related fungi, we predict that the cluster is associated with the production of a terpene. The terpene could be viridin. This is the first report on cloning of secondary metabolism related genes from T. virens, and of their organization in a cluster, in this biocontrol fungus.
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