Evidence map›Paper›PMID 16804691›Full record

Trial reportPsychopharmacology2007

Tobacco chippers show robust increases in smoking urge after alcohol consumption.

Alyssa M Epstein, Tamara G Sher, Michael A Young, Andrea C King

Registry-linked trialAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Psychopharmacology, 2007. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00961792 (Individual Differences After Consumption of Alcohol and Other Common Substances and Long-Term Follow-Up of Social Drinking, Young Adults), which is not on this map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00961792 naactive not recruitingnot on this map

Individual Differences After Consumption of Alcohol and Other Common Substances and Long-Term Follow-Up of Social Drinking, Young Adults

TypeinterventionalSponsorUniversity of ChicagoRan2004 to 2027Enrolled800ConditionsAlcoholismArmsEthanol, Placebo, Diphenhydramine, Caffeine
3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  11. Preliminary findings on the interactive effects of IV ethanol and IV nicotine on human behavior and cognition: a laboratory study.Nicotine & tobacco research : official journal of the Society for Research on Nicotine and Tobacco · 2012
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  15. Neural substrates of alcohol-induced smoking urge in heavy drinking nondaily smokers.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2010
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alyssa M EpsteinInstitute of Psychology, Illinois Institute of Technology, Chicago, IL, USA.
Tamara G Sher
Michael A Young
Andrea C King

Funding

ZOLEDRONATE &OSTEOPOROTIC EFFECTS OF ANDROGEN DEPRIVATIM01RR000055 · NCRR · UNIVERSITY OF CHICAGO · PI GARFINKEL, MARC R · 1985 to 2007
$19.0M
Alcohol Stimulation and Sedation in Binge Drinkers - Renewal 01R01AA013746 · NIAAA · UNIVERSITY OF CHICAGO · PI DANIEL J FRIDBERG, ANDREA C KING · 2003 to 2026
$11.6M
Alcohol Effects on Smoking Urge and BehaviorR03AA015337 · NIAAA · UNIVERSITY OF CHICAGO · PI KING, ANDREA C · 2005 to 2006
$151k
Acute Alcohol and Nicotine Interactions in Men and WomenF31AA015017 · NIAAA · ILLINOIS INSTITUTE OF TECHNOLOGY · PI EPSTEIN, ALYSSA M · 2004 to 2005
$64k
NCRR NIH HHS M01-RR00055NIAAA NIH HHS F31-AA15017NIAAA NIH HHS R01-AA013746NIAAA NIH HHS R03-AA015337
6 · The paper itself

Abstract

objective and rationaleHeavy social drinkers often engage in occasional cigarette smoking, especially in the context of consuming large quantities of alcohol. The current study assessed alcohol's effects on smoking urge as a function of alcohol dose and time course in tobacco chippers with heavy social drinking patterns.

methodThe study assessed 39 chippers who underwent three separate evening sessions. Each subject received a placebo (1% volume alcohol as a taste mask), a low alcohol dose (two to three drinks equivalent), and a high alcohol dose (four to five drinks equivalent) in random order. No smoking was permitted during the sessions and the participants were abstinent from smoking for at least 3 h before arrival. Throughout the session, cigarette craving was assessed by the Brief Questionnaire of Smoking Urges and alcohol response was assessed by the Biphasic Alcohol Effects Scale (BAES).

resultsThe results showed that alcohol significantly increased cigarette craving in a dose-dependent manner (p<0.001). At the high alcohol dose, craving was heightened during the rising portion of the blood alcohol curve (BAC). There was a strong relationship between BAC and craving for positive reinforcement and this relationship was partially mediated by BAES stimulation, but not sedation.

conclusionsThe findings show that alcohol directly increases smoking urge in chipper smokers. Tobacco chippers may crave cigarettes more during heavier than during lighter drinking bouts, and this effect appears to be driven by heightened stimulation levels rather than as a means to offset alcohol's sedative effects.

Indexed as

CuesAdultAlcohol DrinkingBehaviorDose-Response Relationship, DrugEthanolFemaleHumansMaleModels, PsychologicalPsychopharmacologyReinforcement, PsychologySmokingSurveys and QuestionnairesTobacco Use DisorderEthanol

Identifiers

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.