ArticleCMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne2006
Outbreak in Alberta of community-acquired (USA300) methicillin-resistant Staphylococcus aureus in people with a history of drug use, homelessness or incarceration.
Article in CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 83 papers, 1 of them a synthesis that pooled it.
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83 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Methicillin-resistant Staphylococcus aureus (MRSA) in men having sex with men (MSM): a systematic review.BMC infectious diseases · 2025Pooled it
- Bacterial Carriage and Invasive Infections Among People Who Inject Drugs: Clinical and Molecular Epidemiology in an Australian Prospective Cohort.Open forum infectious diseases · 2026Article
- Molecular typing of PVL-positive Staphylococcus aureus isolates from Lithuania and genome sequencing of a local outbreak strain.Scientific reports · 2026Article
- Social determinants and community-level risk factors in CA-MRSA transmission among disadvantaged populations in North America: A scoping review.Epidemiology and infection · 2025Article
- Mapping socioeconomic factors driving antimicrobial resistance in humans: An umbrella review.One health (Amsterdam, Netherlands) · 2025Review
- Methods for Quantifying the Metabolic Boundary Fluxes of Cell Cultures in Large Cohorts by High-Resolution Hydrophilic Liquid Chromatography Mass Spectrometry.Analytical chemistry · 2022Article
- Dimensions of poverty as risk factors for antimicrobial resistant organisms in Canada: a structured narrative review.Antimicrobial resistance and infection control · 2022Review
- A Murine Skin Infection Model Capable of Differentiating the Dermatopathology of Community-Associated MRSA Strain USA300 from Other MRSA Strains.Microorganisms · 2021Article
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- Longitudinal evaluation of risk factors and outcomes of blood stream infections due toEClinicalMedicine · 2021Article
- Antimicrobial Resistance in ESKAPE Pathogens.Clinical microbiology reviews · 2020Review
- Molecular Characterization and Pathogenicity ofMicroorganisms · 2020Article
- Arginine Catabolic Mobile Element in Evolution and Pathogenicity of the Community-Associated Methicillin-ResistantMicroorganisms · 2020Article
- Staphylococcus aureus nasal carriage among homeless population in Lisbon, Portugal.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019Article
- Sociodemographic and geospatial associations with community-associated methicillin-resistant Staphylococcus aureus (CA-MRSA) infections in a large Canadian city: an 11 year retrospective study.BMC public health · 2019Article
- Complete Genome Sequences of Two USA300-Related Community-Associated Methicillin-Resistant Staphylococcus aureus Clinical Isolates.Microbiology resource announcements · 2019Article
- Clonal expansion of community-associated meticillin-resistant Staphylococcus aureus (MRSA) in people who inject drugs (PWID): prevalence, risk factors and molecular epidemiology, Bristol, United Kingdom, 2012 to 2017.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019Article
- Outcomes of hip and knee total joint arthroplasty in a Canadian inmate population over a 10-year periodCanadian journal of surgery. Journal canadien de chirurgie · 2018Article
- Methicillin-Resistant Staphylococcus aureus: Molecular Characterization, Evolution, and Epidemiology.Clinical microbiology reviews · 2018Review
23 more citing papers are in PubMed but not listed here.
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17 authors.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundThe USA300 strain of community-acquired methicillin-resistant Staphylococcus aureus (CA-MRSA) can cause severe infection and is increasingly recognized as a cause of community outbreaks. In 2004, an outbreak was identified in the Calgary Health Region (CHR).
methodsMRSA isolates were identified with standard methods at a central regional laboratory and typed via pulsed-field gel electrophoresis (PFGE). Isolates were tested by PCR for mecA, Panton-Valentine leukocidin (PVL), SCCmec, and spa genes. Cases were defined as such if a clinical isolate of the USA300 strain was noted between January 1 and September 30, 2004, and the patient had lived or traveled in CHR within 2 years before symptom onset. Demographic, clinical and risk data on all such cases were collected from several sources for statistical analysis. A case was defined as high-risk if the patient had a history of drug use, homelessness or incarceration.
resultsOf 40 isolates with the USA300 PFGE pattern, all tested positive for PVL, SCCmec type IVa and spa type 008. Almost all infections (39/40, 98%) involved skin and soft tissues, except for 1 death from necrotizing hemorrhagic pneumonia; a notable proportion (38%) required hospital admission or intravenous antimicrobial therapy. The outbreak centred on the high-risk population in CHR (70%; risk ratio 169.4, 95% confidence interval 86.1-333.0).
interpretationPeople with histories of illicit drug use, homelessness or recent incarceration were at highest risk for infection with CA-MRSA. The emergence and spread of this virulent strain has important implications for treatment and public health in Canada.
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