ArticleProceedings of the National Academy of Sciences of the United States of America2006
The C2H2 zinc-finger protein SYD-9 is a putative posttranscriptional regulator for synaptic transmission.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 17 citations in OpenAlex.
- The novel nematicide wact-86 interacts with aldicarb to kill nematodes.PLoS neglected tropical diseases · 2017Article
- A Systematic RNAi Screen Reveals a Novel Role of a Spindle Assembly Checkpoint Protein BuGZ in Synaptic Transmission inFrontiers in molecular neuroscience · 2017Article
- Decreased function of survival motor neuron protein impairs endocytic pathways.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- A role of the LIN-12/Notch signaling pathway in diversifying the non-striated egg-laying muscles in C. elegans.Developmental biology · 2014Article
- Uncovering buffered pleiotropy: a genome-scale screen for mel-28 genetic interactors in Caenorhabditis elegans.G3 (Bethesda, Md.) · 2014Article
- Regulatory roles of RNA binding proteins in the nervous system of C. elegans.Frontiers in molecular neuroscience · 2014Review
- Expanding views of presynaptic terminals: new findings from Caenorhabditis elegans.Current opinion in neurobiology · 2012Review
- C. elegans PAT-9 is a nuclear zinc finger protein critical for the assembly of muscle attachments.Cell & bioscience · 2012Article
- A widespread distribution of genomic CeMyoD binding sites revealed and cross validated by ChIP-Chip and ChIP-Seq techniques.PloS one · 2010Article
- Nuclear pre-mRNA 3'-end processing regulates synapse and axon development in C. elegans.Development (Cambridge, England) · 2010Article
- Caenorhabditis elegans innexins regulate active zone differentiation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2009Article
- ITSN-1 controls vesicle recycling at the neuromuscular junction and functions in parallel with DAB-1.Traffic (Copenhagen, Denmark) · 2008Article
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 2 countries.
Funding
Abstract
Communication between neurons is largely achieved through chemical synapses, where neurotransmitters are released from synaptic vesicles at presynaptic terminals to activate postsynaptic cells. Exo- and endocytosis are coordinated to replenish the synaptic vesicle pool for sustained neuronal activity. We identified syd-9 (syd, synapse defective), a gene that encodes multiple C2H2 zinc-finger domain-containing proteins specifically required for synaptic function in Caenorhabditis elegans. syd-9 loss-of-function mutants exhibit locomotory defects, a diffuse distribution of synaptic proteins, and decreased synaptic transmission with unaffected neurodevelopment. syd-9 mutants share phenotypic and ultrastructural characteristics with mutants that lack synaptic proteins that are required for endocytosis. syd-9 mutants also display genetic interactions with these endocytotic mutants, suggesting that SYD-9 regulates endocytosis. SYD-9 proteins are enriched in the nuclei of both neuron and muscle cells, but their neuronal expression plays a major role in locomotion. SYD-9 isoforms display a speckle-like expression pattern that is typical of RNA-binding proteins that regulate premRNA splicing. Furthermore, syd-9 functions in parallel with unc-75 (unc, uncoordinated), the C. elegans homologue of the CELF/BrunoL family protein that regulates mRNA alternative splicing and processing, and is also required specifically for synaptic transmission. We propose that neuronal SYD-9 proteins are previously uncharacterized and specific posttranscriptional regulators of synaptic vesicle endocytosis.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.