ArticleAmerican journal of physiology. Endocrinology and metabolism2006
Pioglitazone increases secretion of high-molecular-weight adiponectin from adipocytes.
Article in American journal of physiology. Endocrinology and metabolism, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It reports registered trial NCT00108615. Cited by 41 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance
Who cites it
41 citing papers in PubMed, 120 citations in OpenAlex.
- Regulation of small ubiquitin-like modifier-1, nuclear receptor coreceptor, histone deacetylase 3, and peroxisome proliferator-activated receptor-γ in human adipose tissue.Metabolic syndrome and related disorders · 2012Trial
- Selective regulation of cellular and secreted multimeric adiponectin by antidiabetic therapies in humans.American journal of physiology. Endocrinology and metabolism · 2009Trial
- Effect of pioglitazone treatment on endoplasmic reticulum stress response in human adipose and in palmitate-induced stress in human liver and adipose cell lines.American journal of physiology. Endocrinology and metabolism · 2008Trial
- Efficacy and safety of SGLT2 inhibitor on insulin resistance and hyperglycemia in Werner syndrome-A case report.Journal of diabetes investigation · 2026Article
- 20 Years with SGBS cells - a versatile in vitro model of human adipocyte biology.International journal of obesity (2005) · 2022Review
- The Role of Anti-Inflammatory Adipokines in Cardiometabolic Disorders: Moving beyond Adiponectin.International journal of molecular sciences · 2021Review
- Androstenedione changes steroidogenic activity of SGBS cells.Endocrine connections · 2020Article
- Examining the Potential of Developing and Implementing Use of Adiponectin-Targeted Therapeutics for Metabolic and Cardiovascular Diseases.Frontiers in endocrinology · 2019Review
- Pioglitazone Inhibits Periprostatic White Adipose Tissue Inflammation in Obese Mice.Cancer prevention research (Philadelphia, Pa.) · 2018Article
- Adiponectin Suppresses T Helper 17 Cell Differentiation and Limits Autoimmune CNS Inflammation via the SIRT1/PPARγ/RORγt Pathway.Molecular neurobiology · 2017Article
- The Influence of a KDT501, a Novel Isohumulone, on Adipocyte Function in Humans.Frontiers in endocrinology · 2017Article
- Adiponectin serum level in chronic hepatitis C infection and therapeutic profile.World journal of hepatology · 2015Review
- Osmotin: a plant sentinel and a possible agonist of mammalian adiponectin.Frontiers in plant science · 2015Review
- Higher omega-3 index is associated with increased insulin sensitivity and more favourable metabolic profile in middle-aged overweight men.Scientific reports · 2014Article
- Assembly of adiponectin oligomers.Reviews in endocrine & metabolic disorders · 2014Review
- Effects of interventions on adiponectin and adiponectin receptors.Journal of exercise rehabilitation · 2014Review
- Adiponectin gene variants, adiponectin isoforms and cardiometabolic risk in type 2 diabetic patients.Journal of diabetes investigation · 2014Article
- Molecular pathways: adiponectin and leptin signaling in cancer.Clinical cancer research : an official journal of the American Association for Cancer Research · 2013Review
- Obesity pharmacotherapy: current perspectives and future directions.Current cardiology reviews · 2013Review
- The SGBS cell strain as a model for the in vitro study of obesity and cancer.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2012Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Adiponectin is an adipocyte-derived serum protein that plays important roles in energy homeostasis, obesity, and insulin sensitivity. Using sucrose gradients and Western blotting of nondenaturing gels, we examined the adiponectin isoforms secreted from human adipose tissue, human and mouse adipocytes, and cell lines in response to pioglitazone added in vitro. The predominant form secreted from adipose tissue in vitro was the high-molecular-weight (HMW) isoform, with small amounts of low-molecular-weight (LMW) forms present. The addition of pioglitazone (1-3 micromM) in vitro increased the secretion of the HMW isoform, with no significant effect on the other isoforms. Human adipose tissue was also examined for changes in adiponectin mRNA levels upon pioglitazone treatment. No difference was detected, suggesting that the effect of pioglitazone is not at the transcriptional level but, rather, at a posttranscriptional phase of the secretory pathway. Additional experiments were conducted to determine whether adiponectin expression was mechanistically similar in other adipose cells. Examination of primary human adipocytes revealed an increase in intracellular HMW isoform with a decline in LMW forms following pioglitazone treatment, with a corresponding increase in the secreted HMW form. Similar results were observed with primary mouse adipocytes, 3T3-F422A cells, and SGBS human adipocyte cells, although differences in the distribution of HMW and LMW isoforms were apparent between cell types. Although there are differences in isoforms between species, in all cases pioglitazone served to increase the secretion of the HMW form of adiponectin.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.