ArticleMolecular genetics and genomics : MGG2006
Wide mutational spectrum of a gene involved in hormone action and insecticide resistance in Drosophila melanogaster.
Article in Molecular genetics and genomics : MGG, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 30 citations in OpenAlex.
- Evaluation of ebony as a potential selectable marker for genetic sexing in Aedes aegypti.Parasites & vectors · 2025Article
- Juvenile hormones direct primordial germ cell migration to the embryonic gonad.Current biology : CB · 2024Article
- Juvenile hormone receptor Methoprene tolerant: Functions and applications.Vitamins and hormones · 2023Article
- Juvenile hormone regulates body size and perturbs insulin signaling in Drosophila.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
- Regulation of onset of female mating and sex pheromone production by juvenile hormone in Drosophila melanogaster.Proceedings of the National Academy of Sciences of the United States of America · 2013Article
- A role for juvenile hormone in the prepupal development of Drosophila melanogaster.Development (Cambridge, England) · 2010Article
- Suppressed production of methyl farnesoid hormones yields developmental defects and lethality in Drosophila larvae.General and comparative endocrinology · 2010Article
- bHLH-PAS family transcription factor methoprene-tolerant plays a key role in JH action in preventing the premature development of adult structures during larval-pupal metamorphosis.Mechanisms of development · 2008Article
- Overexpression of Methoprene-tolerant, a Drosophila melanogaster gene that is critical for juvenile hormone action and insecticide resistance.Insect biochemistry and molecular biology · 2008Article
- Identification and characterization of a juvenile hormone response element and its binding proteins.The Journal of biological chemistry · 2007Article
- Juvenile hormone resistance gene Methoprene-tolerant controls entry into metamorphosis in the beetle Tribolium castaneum.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Drosophila melanogaster Methoprene-tolerant (Met) gene homologs from three mosquito species: Members of PAS transcriptional factor family.Journal of insect physiology · 2007Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
Abstract
The Methoprene-tolerant (Met) bHLH-PAS gene in Drosophila melanogaster is involved in the molecular action of juvenile hormone (JH), and mutants result in resistance to the toxic and morphogenetic effects of JH and JH agonist insecticides such as methoprene. A detailed study of Met mutants can shed light on the poorly understood action of JH as well as the molecular basis of Met resistance to JH insecticides. Nine mutant alleles bearing point mutations in Met were examined for penetrance and expressivity of three phenotypic characters: resistance, defective oogenesis, and a novel eye defect. The collection ranged from two weak alleles having less severe phenotypes to strong alleles with severe phenotypes similar to that of a null allele. The point mutations were located in both conserved and nonconserved domains. Both the eye defect, seen as severely malformed ommatidial facets in the posterior margin of the compound eye, and the oogenesis phenotype are nonconditional, whereas expression of the resistance phenotype requires treatment with JH or JH analogs (JHAs) during early metamorphosis. A proposed basis for all the phenotypic characters centers on MET action as a transcriptional regulator of ecdysone secondary-response target genes during metamorphosis. Disruption of MET function either by mutation or by JHA presence during early metamorphosis results in transcriptional misregulation of different target genes, resulting in the pathology seen in either instance. The variety of amino acid changes in MET that resulted in resistance may portend a rapid rise in resistance in response to increased use of JH insecticides in field insect populations.
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