Evidence map›Paper›PMID 16801962›Full record

ReviewJournal of perinatology : official journal of the California Perinatal Association2006

Early postnatal nutritional requirements of the very preterm infant based on a presentation at the NICHD-AAP workshop on research in neonatology.

W W Hay

Abstract readReview
PubMed Publisher
In one paragraph

Review in Journal of perinatology : official journal of the California Perinatal Association, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
3.3field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 38 citations in OpenAlex.

  1. Article
  2. Observational
  3. Article
  4. Article
  5. Article
  6. Maternal obesity and fetal metabolic programming: a fertile epigenetic soil.American journal of physiology. Regulatory, integrative and comparative physiology · 2010
    Review
  7. Improved growth and decreased morbidities in <1000 g neonates after early management changes.Journal of perinatology : official journal of the California Perinatal Association · 2008
    Article
  8. Review
  9. Multivariate analysis of hyperglycemia in extremely low birth weight infants.Journal of perinatology : official journal of the California Perinatal Association · 2006
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

W W HayNeonatal Clinical Research Center and the UCHSC Perinatal Research Center, University of Colorado Health Sciences Center, Aurora, 80045, USA. bill.hay@uchsc.edu
University of Colorado Health · US

Funding

Training Program in Perinatal Biology and MedicineT32HD007186 · NICHD · UNIVERSITY OF COLORADO DENVER · PI Paul Joseph Rozance · 1985 to 2026
$6.5M
REGULATION OF PLACENTAL METABOLISM BY GLUCOSE SUPPLYR01HD028794 · NICHD · UNIVERSITY OF COLORADO DENVER · PI HAY, WILLIAM W · 1992 to 2006
$2.5M
FETAL GLUCOSE AND AMINO ACID DEPRIVATIONR01DK052138 · NIDDK · UNIVERSITY OF COLORADO DENVER · PI HAY, WILLIAM W · 1997 to 2005
$1.9M
NICHD NIH HHS R01 HD28794NICHD NIH HHS R01 HD42812NICHD NIH HHS T32 HD07186NIDDK NIH HHS R01 DK52138
6 · The paper itself

Abstract

Normal fetal nutrition is a useful guide for understanding postnatal nutrition of infants born very preterm. Fetal lipid uptake gradually increases towards term and is primarily used to produce fat in adipose tissue, with essential fatty acid uptake providing necessary structural and functional elements in membranes of cells in the central nervous system. Fetal glucose uptake and utilization rates are nearly twice as high at 23-26 weeks gestation as they are at term, contributing primarily to energy production and glycogen formation. Amino-acid uptake by the fetus is two-to threefold greater at 23-26 weeks gestation than at term and is required to meet the very high fractional protein synthesis and growth rates at this gestational period; amino acids also contribute significantly to fetal energy production. In contrast, after birth most of the very preterm infants are fed more lipid and glucose and less amino acids and protein than they need. Not surprisingly, therefore, very preterm infants accumulate fat but remain relatively growth restricted at term gestational age compared to those infants who grew normally in utero, and this postnatal growth restriction has long-term adverse growth, development, and health consequences. More thorough understanding of the unique nutritional, metabolic, and growth requirements of the normally growing fetus and the very preterm infant, once born, are needed to determine optimal nutritional strategies to improve the outcome of preterm infants.

Indexed as

Infant, PrematureNutritional RequirementsAmino AcidsAnimalsFetusGlucoseHumansInfant, NewbornLipid MetabolismOxygen ConsumptionAmino AcidsGlucose

Identifiers

PMID16801962
OpenAlexW2040837653

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.