Evidence map›Paper›PMID 16801448›Full record

ArticleAntimicrobial agents and chemotherapy2006

Characterizing the effects of caspofungin on Candida albicans, Candida parapsilosis, and Candida glabrata isolates by simultaneous time-kill and postantifungal-effect experiments.

Cornelius J Clancy, Hong Huang, Shaoji Cheng, Hartmut Derendorf, M Hong Nguyen

Registry-linked trialOpen access · greenAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02644135 (A Pilot Study of the Safety, Tolerability, and Effectiveness of Halo to Prevent Acute Upper Respiratory Disease and Respiratory Virus Infections), which is not on this map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02644135 nacompletednot on this mapstarted 2013, after this paper: background citation

A Pilot Study of the Safety, Tolerability, and Effectiveness of Halo to Prevent Acute Upper Respiratory Disease and Respiratory Virus Infections

TypeinterventionalSponsorUniversity Hospitals Cleveland Medical CenterRan2013 to 2013Enrolled100ConditionsHealthyArmsHalo Oral Spray, Halo Placebo
3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 73 citations in OpenAlex.

  1. Review
  2. Metal Nanoparticles to CombatMicroorganisms · 2023
    Review
  3. Review
  4. Postantifungal Effect of Antifungal Drugs againstJournal of fungi (Basel, Switzerland) · 2022
    Review
  5. Review
  6. Article
  7. Review
  8. Evaluation of a novel oxiconazole nitrate formulation: The thermosensitive gel.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018
    Article
  9. Article
  10. Article
  11. Methods forJournal of pharmaceutical analysis · 2016
    Review
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Cornelius J ClancyNorth Florida/South Georgia VA Medical Center, University of Florida College of Medicine, Gainesville, FL 32610, USA. clancyn@medicine.ufl.edu
Hong Huang
Shaoji Cheng
Hartmut Derendorf
M Hong Nguyen
Florida College · USNorth Florida/South Georgia Veterans Health System · USUniversity of Florida · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We measured time-kills and postantifungal effects (PAFEs) of caspofungin against Candida albicans, C. parapsilosis, and C. glabrata isolates. One-hour exposure to caspofungin during PAFE experiments accounted for the majority of killing during time-kill experiments. Regrowth of all isolates was inhibited for at least 24 h following drug washout.

Indexed as

Antifungal AgentsCandidaCandida albicansCandida glabrataCaspofunginColony Count, MicrobialEchinocandinsHumansLipopeptidesMicrobial Sensitivity TestsPeptides, CyclicTime FactorsAntifungal AgentsCaspofunginEchinocandinsLipopeptidesPeptides, Cyclic

Identifiers

PMID16801448
PMCPMC1489803
OpenAlexW2128658496

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.