Evidence map›Paper›PMID 16801443›Full record

ArticleAntimicrobial agents and chemotherapy2006

Polyphenols reduce gastritis induced by Helicobacter pylori infection or VacA toxin administration in mice.

P Ruggiero, F Tombola, G Rossi, L Pancotto, L Lauretti, G Del Giudice, M Zoratti

Open access · bronzeAbstract read
In one paragraph

Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
2.1field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 35 citations in OpenAlex.

  1. [Association between dietary habits andZhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2025
    Article
  2. Review
  3. Review
  4. Article
  5. Article
  6. Article
  7. Oxidative medicine and cellular longevity · 2018
    Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

P RuggieroChiron s.r.l., Research Center, Via Fiorentina 1, I-53100 Siena, Italy. paolo_ruggiero@chiron.com
F Tombola
G Rossi
L Pancotto
L Lauretti
G Del Giudice
M Zoratti
Chiron (Norway) · NONeuroscience Institute · ITUniversità di Camerino · ITUniversity of Padua · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Helicobacter pylori colonizes the human gastric mucosa, causing inflammation that leads to atrophic gastritis, and it can cause peptic ulcer and gastric cancer. We show that polyphenol administration to mice experimentally infected by H. pylori or treated with VacA toxin can limit gastric epithelium damage, an effect that may be linked to VacA inhibition.

Indexed as

AnimalsBacterial ProteinsColony Count, MicrobialFlavonoidsGastric MucosaGastritisHelicobacter InfectionsHelicobacter pyloriHumansMiceMice, Inbred BALB CPhenolsPolyphenolsSpecific Pathogen-Free OrganismsTanninsBacterial ProteinsFlavonoidsPhenolsPolyphenolsTanninsVacA protein, Helicobacter pylori

Identifiers

PMID16801443
PMCPMC1489755
OpenAlexW2017085862

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.