ArticleAntimicrobial agents and chemotherapy2006
Quinolones sensitize gram-negative bacteria to antimicrobial peptides.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 30 citations in OpenAlex.
- Identification and biological characterization of the novel pathogen responsible for cataract in bullfrogs.Veterinary research communications · 2026Article
- Mammals' humoral immune proteins and peptides targeting the bacterial envelope: from natural protection to therapeutic applications against multidrug-resistant Gram-negatives.Biological reviews of the Cambridge Philosophical Society · 2022Review
- Colistin Interaction and Surface Changes Associated withPharmaceutics · 2022Article
- Clinically Relevant Epithelial Lining Fluid Concentrations of Meropenem with Ciprofloxacin Provide Synergistic Killing and Resistance Suppression of Hypermutable Pseudomonas aeruginosa in a Dynamic Biofilm Model.Antimicrobial agents and chemotherapy · 2020Article
- Klebsiella pneumoniae infection biology: living to counteract host defences.FEMS microbiology reviews · 2019Review
- Enhancing the antibacterial activity of polymyxins using a nonantibiotic drug.Infection and drug resistance · 2019Article
- Meropenem Combined with Ciprofloxacin Combats Hypermutable Pseudomonas aeruginosa from Respiratory Infections of Cystic Fibrosis Patients.Antimicrobial agents and chemotherapy · 2018Article
- Synergism in dual functionality of cryptdin-2 in conjunction with antibiotics againstThe Indian journal of medical research · 2016Article
- Essential Oils and Their Components as Modulators of Antibiotic Activity against Gram-Negative Bacteria.Medicines (Basel, Switzerland) · 2016Review
- Haemophilus influenzae induces steroid-resistant inflammatory responses in COPD.BMC pulmonary medicine · 2015Article
- Antimicrobial Effects and Resistant Regulation of Magnolol and Honokiol on Methicillin-Resistant Staphylococcus aureus.BioMed research international · 2015Article
- Efficacy of cryptdin-2 as an adjunct to antibiotics from various generations against salmonella.Indian journal of microbiology · 2014Article
- Surface changes and polymyxin interactions with a resistant strain of Klebsiella pneumoniae.Innate immunity · 2014Article
- Article
- Bacteriostatic antimicrobial combination: antagonistic interaction between epsilon-viniferin and vancomycin against methicillin-resistant Staphylococcus aureus.BioMed research international · 2014Article
- Design, synthesis, and evaluation of a new fluorescent probe for measuring polymyxin-lipopolysaccharide binding interactions.Analytical biochemistry · 2011Article
- Structural features governing the activity of lactoferricin-derived peptides that act in synergy with antibiotics against Pseudomonas aeruginosa in vitro and in vivo.Antimicrobial agents and chemotherapy · 2011Article
- The plasmid-encoded regulator activates factors conferring lysozyme resistance on enteropathogenic Escherichia coli strains.Applied and environmental microbiology · 2009Article
- Klebsiella pneumoniae OmpA confers resistance to antimicrobial peptides.Antimicrobial agents and chemotherapy · 2009Article
- Characterization and biological role of the O-polysaccharide gene cluster of Yersinia enterocolitica serotype O:9.Journal of bacteriology · 2007Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The treatment of infections caused by bacteria resistant to the vast majority of antibiotics is a challenge worldwide. Antimicrobial peptides (APs) make up the front line of defense in those areas exposed to microorganisms, and there is intensive research to explore their use as new antibacterial agents. On the other hand, it is known that subinhibitory concentrations of antibiotics affect the expression of numerous bacterial traits. In this work we evaluated whether treatment of bacteria with subinhibitory concentrations of quinolones may alter the sensitivity to APs. A 1-h treatment of Klebsiella pneumoniae with 0.25 x the MIC of ciprofloxacin rendered bacteria more sensitive to polymyxins B and E, human neutrophil defensin 1, and beta-defensin 1. Levofloxacin and nalidixic acid at 0.25 x the MICs also increased the sensitivity of K. pneumoniae to polymyxin B, whereas gentamicin and ceftazidime at 0.25 x the MICs did not have such an effect. Ciprofloxacin also increased the sensitivities of K. pneumoniae ciprofloxacin-resistant strains to polymyxin B. Two other pathogens, Pseudomonas aeruginosa and Haemophilus influenzae, also became more sensitive to polymyxins B and E after treatment with 0.25 x the MIC of ciprofloxacin. Incubation with ciprofloxacin did not alter the expression of the K. pneumoniae loci involved in resistance to APs. A 1-N-phenyl-naphthylamine assay showed that ciprofloxacin and levofloxacin increased the permeabilities of the K. pneumoniae and P. aeruginosa outer membranes, while divalent cations antagonized this action. Finally, we demonstrated that ciprofloxacin and levofloxacin increased the binding of APs to the outer membrane by using dansylated polymyxin B.
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