ArticleAntimicrobial agents and chemotherapy2006
Multiple cis-acting sequences mediate upregulation of the MDR1 efflux pump in a fluconazole-resistant clinical Candida albicans isolate.
Article in Antimicrobial agents and chemotherapy, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 37 citations in OpenAlex.
- Transcriptional Response of Candida auris to the Mrr1 Inducers Methylglyoxal and Benomyl.mSphere · 2022Article
- The influence of tea tree oil (Melaleuca alternifolia) on fluconazole activity against fluconazole-resistant Candida albicans strains.BioMed research international · 2015Article
- Multidrug-resistant transporter mdr1p-mediated uptake of a novel antifungal compound.Antimicrobial agents and chemotherapy · 2013Article
- Inducible and constitutive activation of two polymorphic promoter alleles of the Candida albicans multidrug efflux pump MDR1.Antimicrobial agents and chemotherapy · 2012Article
- Antifungal resistance and new strategies to control fungal infections.International journal of microbiology · 2012Article
- An MDR1 promoter allele with higher promoter activity is common in clinically isolated strains of Candida albicans.Molecular genetics and genomics : MGG · 2011Article
- Regulation of efflux pump expression and drug resistance by the transcription factors Mrr1, Upc2, and Cap1 in Candida albicans.Antimicrobial agents and chemotherapy · 2011Article
- Differential requirement of the transcription factor Mcm1 for activation of the Candida albicans multidrug efflux pump MDR1 by its regulators Mrr1 and Cap1.Antimicrobial agents and chemotherapy · 2011Article
- The zinc cluster transcription factor Ahr1p directs Mcm1p regulation of Candida albicans adhesion.Molecular microbiology · 2011Article
- Functional analysis of cis- and trans-acting elements of the Candida albicans CDR2 promoter with a novel promoter reporter system.Eukaryotic cell · 2009Article
- Identification of the Candida albicans Cap1p regulon.Eukaryotic cell · 2009Article
- Environmental induction of white-opaque switching in Candida albicans.PLoS pathogens · 2008Article
- Stress, drugs, and evolution: the role of cellular signaling in fungal drug resistance.Eukaryotic cell · 2008Review
- Transcriptional activation and increased mRNA stability contribute to overexpression of CDR1 in azole-resistant Candida albicans.Antimicrobial agents and chemotherapy · 2008Article
- The transcription factor Mrr1p controls expression of the MDR1 efflux pump and mediates multidrug resistance in Candida albicans.PLoS pathogens · 2007Article
- Multidrug resistance in fungi.Eukaryotic cell · 2007Review
- Transcriptional regulation of MDR1, encoding a drug efflux determinant, in fluconazole-resistant Candida albicans strains through an Mcm1p binding site.Eukaryotic cell · 2006Article
- Recent insights into the mechanisms of antifungal resistance.Current infectious disease reports · 2006Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Overexpression of the MDR1 gene, which encodes a multidrug efflux pump of the major facilitator superfamily, is a frequent cause of resistance to the antimycotic agent fluconazole and other metabolic inhibitors in clinical Candida albicans strains. Constitutive MDR1 overexpression in such strains is caused by mutations in as yet unknown trans-regulatory factors. In order to identify the cis-acting sequences in the MDR1 regulatory region that mediate constitutive MDR1 upregulation, we performed a promoter deletion analysis in the genetic background of an MDR1-overexpressing clinical C. albicans isolate. We found that several different regions in the MDR1 promoter can mediate MDR1 overexpression in this isolate. In contrast, deletion of one of these regions abolished benomyl-induced MDR1 expression in a C. albicans laboratory strain. These results suggest that multiple transcription factors control expression of the MDR1 efflux pump in C. albicans and that the mutation(s) that causes constitutive MDR1 overexpression and drug resistance in clinical C. albicans isolates affects the activities of several of these transcription factors.
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