ArticleThe Journal of experimental medicine2006
An autosomal dominant major gene confers predisposition to pulmonary tuberculosis in adults.
Article in The Journal of experimental medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed, 121 citations in OpenAlex.
- Article
- The immunogenetics of tuberculosis (TB) susceptibility.Immunogenetics · 2023Review
- Human genetics of Buruli ulcer.Human genetics · 2020Review
- The monogenic basis of human tuberculosis.Human genetics · 2020Review
- Impact of the Polymorphism of theIranian journal of medical sciences · 2019Article
- The Interplay of Human andFrontiers in genetics · 2019Review
- Association of TLR8 and TLR9 polymorphisms with tuberculosis in a Chinese Han population: a case-control study.BMC infectious diseases · 2018Article
- Human genetics of mycobacterial disease.Mammalian genome : official journal of the International Mammalian Genome Society · 2018Review
- Genetics of human susceptibility to active and latent tuberculosis: present knowledge and future perspectives.The Lancet. Infectious diseases · 2018Review
- Mechanistic and topological explanations in medicine: the case of medical genetics and network medicine.Synthese · 2018Article
- New variant identified in major susceptibility locus to tuberculosis on chromosomal region 8q12-q13 in Moroccan population: a case control study.BMC infectious diseases · 2017Article
- SP110 and PMP22 polymorphisms are associated with tuberculosis risk in a Chinese-Tibetan population.Oncotarget · 2016Article
- Major Loci on Chromosomes 8q and 3q Control Interferon γ Production Triggered by Bacillus Calmette-Guerin and 6-kDa Early Secretory Antigen Target, Respectively, in Various Populations.The Journal of infectious diseases · 2016Article
- A genome-wide association study of pulmonary tuberculosis in Morocco.Human genetics · 2016Article
- H3ABioNet, a sustainable pan-African bioinformatics network for human heredity and health in Africa.Genome research · 2016Article
- Article
- Human genetic basis of interindividual variability in the course of infection.Proceedings of the National Academy of Sciences of the United States of America · 2015Review
- Association study of genes controlling IL-12-dependent IFN-γ immunity: STAT4 alleles increase risk of pulmonary tuberculosis in Morocco.The Journal of infectious diseases · 2014Article
- Long-term mortality in patients with pulmonary and extrapulmonary tuberculosis: a Danish nationwide cohort study.Clinical epidemiology · 2014Article
- The CYP7A1 gene rs3808607 variant is associated with susceptibility of tuberculosis in Moroccan population.The Pan African medical journal · 2014Article
Corrections and comments
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Authors and funding
11 authors at 5 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The molecular basis of genetic predisposition to pulmonary tuberculosis in adults remains largely elusive. Few candidate genes have consistently been implicated in tuberculosis susceptibility, and no conclusive linkage was found in two previous genome-wide screens. We report here a genome-wide linkage study in a total sample of 96 Moroccan multiplex families, including 227 siblings with microbiologically and radiologically proven pulmonary tuberculosis. A genome-wide scan conducted in half the sample (48 families) identified five regions providing suggestive evidence (logarithm of the odds [LOD] score >1.17; P < 0.01) for linkage. These regions were then fine-mapped in the total sample of 96 families. A single region of chromosome 8q12-q13 was significantly linked to tuberculosis (LOD score = 3.49; P = 3 x 10(-5)), indicating the presence of a major tuberculosis susceptibility gene. Linkage was stronger (LOD score = 3.94; P = 10(-5)) in the subsample of 39 families in which one parent was also affected by tuberculosis, whereas it was much lower (LOD score = 0.79) in the 57 remaining families without affected parents, supporting a dominant mode of inheritance of the major susceptibility locus. These results provide direct molecular evidence that human pulmonary tuberculosis has a strong genetic basis, and indicate that the genetic component involves at least one major locus with a dominant susceptibility allele.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.