ArticleTheoretical biology & medical modelling2006
The paradoxical effects of splenectomy on tumor growth.
Article in Theoretical biology & medical modelling, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 31 citations in OpenAlex.
- Tumor-Induced Rewiring of Splenic Niches: from Immune Organ to Cancer Accomplice.International journal of biological sciences · 2026Review
- The Impact of Heterotopic Spleen Regeneration on Tumor Growth.FASEB bioAdvances · 2026Article
- Organ Crosstalk: The Role of Spleen.Phenomics (Cham, Switzerland) · 2025Review
- Splenectomy has opposite effects on the growth of primary compared with metastatic tumors in a murine colon cancer model.Scientific reports · 2024Article
- Splenectomy as Part of Maximal-Effort Cytoreductive Surgery in Advanced Epithelial Ovarian Cancer.Cancers · 2024Article
- Immunomodulatory effect of splenectomy in lung cancer mouse xenograft models receiving radiation therapy.Radiation oncology journal · 2022Article
- Oncologic outcomes after splenectomy during initial cytoreductive surgery in advanced epithelial ovarian cancer: a nationwide population-based cohort study.Acta obstetricia et gynecologica Scandinavica · 2022Article
- Hematologic dysfunction in cancer: Mechanisms, effects on antitumor immunity, and roles in disease progression.Frontiers in immunology · 2022Review
- Changes in peripheral lymphocyte populations in patients with advanced/recurrent ovarian cancer undergoing splenectomy during cytoreductive surgery.Journal of ovarian research · 2021Article
- Dynamic hematological changes in patients undergoing distal pancreatectomy with or without splenectomy: a population-based cohort study.BMC surgery · 2020Article
- Immune consequences of penfluridol treatment associated with inhibition of glioblastoma tumor growth.Oncotarget · 2017Article
- Splenectomy suppresses growth and metastasis of hepatocellular carcinoma through decreasing myeloid-derived suppressor cells in vivo.Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban · 2016Article
- Splenectomy inhibits non-small cell lung cancer growth by modulating anti-tumor adaptive and innate immune response.Oncoimmunology · 2015Article
- Biphasic effect of a primary tumor on the growth of secondary tumor implants.Journal of cancer research and clinical oncology · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThere is a vast and contradictory literature concerning the effect of the spleen and particularly of splenectomy on tumor growth. Sometimes splenectomy seems to inhibit tumor growth, but in other cases it seems, paradoxically, to facilitate both oncogenesis and the growth of established tumors. APPROACH: In this essay I have selected from this large literature a few papers that seem particularly instructive, in the hope of extracting some understanding of the rules governing this paradoxical behavior.
conclusionIn general, whether splenectomy enhances or inhibits tumor growth seems to depend primarily upon the ratio of spleen to tumor. Small proportions of spleen cells usually stimulate tumor growth, in which case splenectomy is inhibitory. Larger proportions of the same cells, especially if they are from immunized animals, usually inhibit tumor growth, in which case splenectomy results in tumor stimulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.