ArticleDiabetes technology & therapeutics2006
Enzymatic fluorescent microsphere glucose sensors:evaluation of response under dynamic conditions.
Article in Diabetes technology & therapeutics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
13 citing papers in PubMed, 37 citations in OpenAlex.
- Review
- Long-Term Evaluation of Inserted Nanocomposite Hydrogel-Based Phosphorescent Oxygen Biosensors: Evolution of Local Tissue Oxygen Levels and Foreign Body Response.ACS applied bio materials · 2024Article
- Glucose biosensors based on Michael addition crosslinked poly(ethylene glycol) hydrogels with chemo-optical sensing microdomains.Journal of materials chemistry. B · 2023Article
- NIR Luminescent Oxygen-Sensing Nanoparticles for Continuous Glucose and Lactate Monitoring.Biosensors · 2023Article
- Time-resolved flavin adenine dinucleotide fluorescence study of the interaction between immobilized glucose oxidase and glucose.Journal of fluorescence · 2013Article
- Role of porosity in tuning the response range of microsphere-based glucose sensors.Biosensors & bioelectronics · 2011Article
- Glucose sensing by time-resolved fluorescence of sol-gel immobilized glucose oxidase.Sensors (Basel, Switzerland) · 2011Article
- "Smart tattoo" glucose biosensors and effect of coencapsulated anti-inflammatory agents.Journal of diabetes science and technology · 2011Article
- Enhancing the longevity of microparticle-based glucose sensors towards 1 month continuous operation.Biosensors & bioelectronics · 2010Article
- Polyelectrolyte-coated alginate microspheres as drug delivery carriers for dexamethasone release.Drug delivery · 2009Article
- Dissolved core alginate microspheres as "smart-tattoo" glucose sensors.Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference · 2009Article
- Glucose Determination by Means of Steady-state and Time-course UV Fluorescence in Free or Immobilized Glucose Oxidase.Sensors (Basel, Switzerland) · 2007Article
- Microscale enzymatic optical biosensors using mass transport limiting nanofilms. 1. Fabrication and characterization using glucose as a model analyte.Analytical chemistry · 2007Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Most previous attempts at the development of a "smart tattoo" for glucose monitoring in diabetes--implantable fluorescent microspheres that can be implanted intradermally and interrogated transdermally using light--have focused on the encapsulation of a competitive binding assay for glucose within hydrogel microspheres or polyelectrolyte microcapsules. We recently reported on the development of a microsphere sensor based on an enzymatic scheme, combined with an oxygen-quenched fluorescent reporter element. A novel feature of this design is the use of polyelectrolyte multilayer nanofilms, which are assembled stepwise on the surface of the microspheres, for modulation of glucose and oxygen mass transport, allowing them to be designed for sensitive and safe operation within the "oxygen deficit" present in the skin. In this work, a flow-through sensor testing apparatus was used to demonstrate the reversible response of the sensors under controlled, dynamic conditions. The sensors were shown to be sensitive over at least 0-140 mg/dL glucose, with a response time of less than 2 min. This report also identifies some current problems with the approach, and gives potential solutions towards the development of a practical implantable sensor for glucose monitoring in diabetes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.