ArticleLasers in surgery and medicine2006
Magnetic resonance imaging correlated with the histopathological effect of Pd-bacteriopheophorbide (Tookad) photodynamic therapy on the normal canine prostate gland.
Article in Lasers in surgery and medicine, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 54 citations in OpenAlex.
- Prostatic artery embolization: magnetic resonance image (MRI) findings in the early detection of prostate infarction in a canine spontaneous benign prostatic hyperplasia model.Translational andrology and urology · 2021Article
- Photodynamic Therapy for the Treatment and Diagnosis ofFrontiers in chemistry · 2021Review
- Article
- Therapeutic Enhancement of Verteporfin-mediated Photodynamic Therapy by mTOR Inhibitors.Photochemistry and photobiology · 2020Article
- Article
- 3D Registration of mpMRI for Assessment of Prostate Cancer Focal Therapy.Academic radiology · 2017Article
- Oncologic Photodynamic Therapy: Basic Principles, Current Clinical Status and Future Directions.Cancers · 2017Review
- Detection of Treatment Success after Photodynamic Therapy Using Dynamic Contrast-Enhanced Magnetic Resonance Imaging.Theranostics · 2017Article
- An update on focal therapy for prostate cancer.Nature reviews. Urology · 2016Review
- Quantitative Multi-Parametric Magnetic Resonance Imaging of Tumor Response to Photodynamic Therapy.PloS one · 2016Article
- Image-guided Interstitial Photodynamic Therapy for Squamous Cell Carcinomas: Preclinical investigation.Journal of oral and maxillofacial surgery, medicine, and pathology · 2015Article
- Unique diagnostic and therapeutic roles of porphyrins and phthalocyanines in photodynamic therapy, imaging and theranostics.Theranostics · 2012Article
- Focal therapy in prostate cancer: modalities, findings and future considerations.Nature reviews. Urology · 2010Review
- Diffusion-weighted MRI for monitoring tumor response to photodynamic therapy.Journal of magnetic resonance imaging : JMRI · 2010Article
- Imaging and photodynamic therapy: mechanisms, monitoring, and optimization.Chemical reviews · 2010Review
- Imaging tumor variation in response to photodynamic therapy in pancreatic cancer xenograft models.International journal of radiation oncology, biology, physics · 2010Article
- Vascular-targeted photodynamic therapy with BF2-chelated Tetraaryl-Azadipyrromethene agents: a multi-modality molecular imaging approach to therapeutic assessment.British journal of cancer · 2009Article
- Contrast-enhanced ultrasonography for real-time monitoring of interstitial laser thermal therapy in the focal treatment of prostate cancer.Canadian Urological Association journal = Journal de l'Association des urologues du Canada · 2009Article
- Photodynamic therapy for prostate cancer--a review of current status and future promise.Nature clinical practice. Urology · 2009Review
- High-field magnetic resonance imaging of the response of human prostate cancer to Pc 4-based photodynamic therapy in an animal model.Lasers in surgery and medicine · 2007Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 2 countries.
Funding
Abstract
BACKGROUND AND
objectiveTo determine the optimal magnetic resonance imaging (MRI) methodology to assess photodynamic therapy (PDT)-induced histopathological responses in the prostate. STUDY DESIGN/MATERIALS AND
methodsLaparotomy was performed in five healthy dogs. Cylindrical diffuser was placed in the prostates to deliver light of 50-300 J/cm at 150 mW/cm and 763 nm to activate IV-injected Tookad (1 mg/kg b.w.). Fast spin echo (FSE) T2-weighted, post-contrast-enhanced T1-(CE-T1) and diffusion weighted images (DWI) were obtained pre- and 2 days, 7 days, and 1 month post-PDT. Radiological-histopathological correlation was performed at 7 days (n = 4) and 1 month (n = 1) after PDT. A qualitative assessment of signal changes and apparent diffusion coefficient (ADC) mapping was performed.
resultsAt 2 or 7 days post-PDT, there was good spatial correlation between PDT-induced hemorrhagic necrosis and unenhanced regions on CE-T1 images. There was a rapidly and persistently enhancing rim corresponding to edema and inflammation. FSE T2 and DWI showed altered signal but did not clearly define necrosis in all cases. At 1 month, it was hard to correlate MR images to histopathologic changes as they represented a mixture of necrosis and developing fibrosis, which led to a mixed signal intensity and less demarcated contrast enhancement.
conclusionsAt 7 days after PDT, gadolinium DTPA contrast-enhanced MRI is superior to DWI and T2 imaging in assessing the boundary of Tookad PDT-induced tissue necrosis in the normal canine prostate.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.