ReviewJournal of gastroenterology2006
DNA methylation as a marker for the past and future.
Review in Journal of gastroenterology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04031716 (Genetic, Epigenetic, Psychosocial, and Biological Determinants of Post-surgical Pain After Pectus or Spine Surgery), which is not on this map. Cited by 56 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Genetic, Epigenetic, Psychosocial, and Biological Determinants of Post-surgical Pain After Pectus or Spine Surgery
Who cites it
56 citing papers in PubMed, 5 syntheses or guidelines pooled it, 149 citations in OpenAlex.
- Systematic review of bidirectional interaction between gut microbiome, miRNAs, and human pathologies.Frontiers in microbiology · 2025Pooled it
- Aberrant Methylation of RASSF1A Closely Associated with HNSCC, a Meta-Analysis.Scientific reports · 2016Pooled it
- The Correlation of MGMT Promoter Methylation and Clinicopathological Features in Gastric Cancer: A Systematic Review and Meta-Analysis.PloS one · 2016Pooled it
- Association between Ras association domain family 1A promoter methylation and hepatocellular carcinoma: a meta-analysis.World journal of gastroenterology · 2013Pooled it
- Pooled it
- How chronic inflammation fuels carcinogenesis as an environmental epimutagen.Discover oncology · 2025Review
- Combined DNA Methylation and Gastric Microbiome Marker PredictsGut and liver · 2024Article
- Chronic restraint stress promotes gastric epithelial malignant transformation by activating the Akt/p53 signaling pathway via ADRB2.Oncology letters · 2022Article
- Maternal High-Fat Diet ModulatesNutrients · 2021Article
- FGFR3Cell death & disease · 2020Article
- SAMD14 promoter methylation is strongly associated with gene expression and poor prognosis in gastric cancer.International journal of clinical oncology · 2020Article
- Role of microRNAs in the predisposition to gastrointestinal malignancies.World journal of clinical cases · 2020Review
- Mbd2 Mediates Retinal Cell Apoptosis by Targeting the lncRNA Mbd2-AL1/miR-188-3p/Traf3 Axis in Ischemia/Reperfusion Injury.Molecular therapy. Nucleic acids · 2020Article
- Enrichment of Genomic Pathways Based on Differential DNA Methylation Associated With Chronic Postsurgical Pain and Anxiety in Children: A Prospective, Pilot Study.The journal of pain · 2019Observational
- A Chance to Cut Is a Chance to Cure: Endoscopic Submucosal Dissection for Early Gastric Cancer.Digestive diseases and sciences · 2019Article
- Review
- Aberrant methylation ofJournal of Cancer · 2018Article
- Aberrant DNA methylation of theJournal of Cancer · 2018Article
- MBD2 upregulates miR-301a-5p to induce kidney cell apoptosis during vancomycin-induced AKI.Cell death & disease · 2017Article
- Lack of Aberrant Methylation in an Adjacent Area of Left-Sided Colorectal Cancer.Yonsei medical journal · 2017Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aberrant methylation of CpG islands in promoter regions can permanently inactivate tumor-suppressor genes, as mutations and chromosomal abnormalities do. In gastric cancers, CDKN2A, CDH1, and MLH1 are inactivated more frequently by aberrant methylation than by mutations, and novel tumor-suppressor genes inactivated by promoter methylation are being identified. We recently found that Helicobacter pylori (HP), a potent gastric carcinogen, induces aberrant methylation in gastric mucosae. When a panel of CpG islands was examined, some CpG islands were consistently methylated in gastric mucosae of individuals with HP infection, while others were resistant. The amount of methylated DNA molecules in the gastric mucosae (methylation level) fluctuated while active HP infection was present, but decreased after it was no longer present. Among individuals without active HP infection, methylation levels in the gastric mucosae were higher in individuals with gastric cancers than in those without. DNA methylation is emerging as a promising marker for past exposure to carcinogens and future risk of cancers.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.