ArticleNature immunology2006
Ancient evolutionary origin of diversified variable regions demonstrated by crystal structures of an immune-type receptor in amphioxus.
Article in Nature immunology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
30 citing papers in PubMed, 57 citations in OpenAlex.
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- Evidence for the Rapid and Divergent Evolution of Mycoplasmas: Structural and Phylogenetic Analysis of Enolases.Frontiers in molecular biosciences · 2021Article
- Binding mode of the side-by-side two-IgV molecule CD226/DNAM-1 to its ligand CD155/Necl-5.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- The Concerted Action of E2-2 and HEB Is Critical for Early Lymphoid Specification.Frontiers in immunology · 2019Article
- A Soluble Immune Effector Binds Both Fungi and Bacteria via Separate Functional Domains.Frontiers in immunology · 2019Article
- Gut immunity in a protochordate involves a secreted immunoglobulin-type mediator binding host chitin and bacteria.Nature communications · 2016Article
- Structure of a variable lymphocyte receptor-like protein from the amphioxus Branchiostoma floridae.Scientific reports · 2016Article
- Predicting a double mutant in the twilight zone of low homology modeling for the skeletal muscle voltage-gated sodium channel subunit beta-1 (Nav1.4 β1).Computational and structural biotechnology journal · 2015Article
- Crystallization and preliminary X-ray diffraction analysis of a single variable domain of the immunoglobulin superfamily in amphioxus, Amphi-IgSF-V.Acta crystallographica. Section F, Structural biology communications · 2014Article
- Article
- Diversity in recognition of glycans by F-type lectins and galectins: molecular, structural, and biophysical aspects.Annals of the New York Academy of Sciences · 2012Review
- The amphioxus genome provides unique insight into the evolution of immunity.Briefings in functional genomics · 2012Review
- A role for variable region-containing chitin-binding proteins (VCBPs) in host gut-bacteria interactions.Proceedings of the National Academy of Sciences of the United States of America · 2011Article
- VISTA, a novel mouse Ig superfamily ligand that negatively regulates T cell responses.The Journal of experimental medicine · 2011Article
- The basis for haplotype complexity in VCBPs, an immune-type receptor in amphioxus.Immunogenetics · 2010Article
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Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
Although the origins of genes encoding the rearranging binding receptors remain obscure, it is predicted that their ancestral forms were nonrearranging immunoglobulin-type domains. Variable region-containing chitin-binding proteins (VCBPs) are diversified immune-type molecules found in amphioxus (Branchiostoma floridae), an invertebrate that diverged early in deuterostome phylogeny. To study the potential evolutionary relationships between VCBPs and vertebrate adaptive immune receptors, we solved the structures of both a single V-type domain (to 1.15 A) and a pair of V-type domains (to 1.85 A) from VCBP3. The deduced structures show integral features of the ancestral variable-region fold as well as unique features of variable-region pairing in molecules that may reflect characteristics of ancestral forms of diversified immune receptors found in modern-day vertebrates.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.