ArticleEMBO reports2006
Internal ribosome entry sequence-mediated translation initiation triggers nonsense-mediated decay.
Article in EMBO reports, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 20 citations in OpenAlex.
- The function of mRNA quality control in aging and age-related diseases.The Journal of biological chemistry · 2026Review
- Nonsense-mediated mRNA decay and associated splicing patterns in neurodevelopmental disorders.Frontiers in molecular biosciences · 2026Review
- Disease modeling of core pre-mRNA splicing factor haploinsufficiency.Human molecular genetics · 2019Article
- Article
- WIG1 is crucial for AGO2-mediated ACOT7 mRNA silencing via miRNA-dependent and -independent mechanisms.Nucleic acids research · 2017Article
- Interrogating the degradation pathways of unstable mRNAs with XRN1-resistant sequences.Nature communications · 2016Article
- 5-azacytidine inhibits nonsense-mediated decay in a MYC-dependent fashion.EMBO molecular medicine · 2014Article
- Nonsense-mediated decay serves as a general viral restriction mechanism in plants.Cell host & microbe · 2014Article
- Cap-binding complex (CBC).The Biochemical journal · 2014Review
- Nonsense-mediated mRNA decay occurs during eIF4F-dependent translation in human cells.Nature structural & molecular biology · 2013Article
- Inhibition of nonsense-mediated mRNA decay by the natural product pateamine A through eukaryotic initiation factor 4AIII.The Journal of biological chemistry · 2009Article
- NMD resulting from encephalomyocarditis virus IRES-directed translation initiation seems to be restricted to CBP80/20-bound mRNA.EMBO reports · 2008Article
- Upf1 phosphorylation triggers translational repression during nonsense-mediated mRNA decay.Cell · 2008Article
- Proximity of the poly(A)-binding protein to a premature termination codon inhibits mammalian nonsense-mediated mRNA decay.RNA (New York, N.Y.) · 2008Article
- Premature Termination Codons Are Recognized in the Nucleus in A Reading-Frame Dependent Manner.Cell discoveryArticle
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In eukaryotes, a surveillance pathway known as nonsense-mediated decay (NMD) regulates the abundance of messenger RNAs containing premature termination codons (PTCs). In mammalian cells, it has been asserted that the NMD-relevant first round of translation is special and involves initiation by a specific protein heterodimer, the nuclear cap-binding complex (CBC). Arguing against a requirement for CBC-mediated translation initiation, we show that ribosomal recruitment by the internal ribosomal entry sequence of the encephalomyocarditis virus triggers NMD of a PTC-containing transcript under conditions in which ribosome entry from the cap is prohibited. These data generalize the previous model and suggest that translation per se, irrespective of how it is initiated, can mediate NMD.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.