ArticlePlant physiology2006
Activation of Ntf4, a tobacco mitogen-activated protein kinase, during plant defense response and its involvement in hypersensitive response-like cell death.
Article in Plant physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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41 citing papers in PubMed, 91 citations in OpenAlex.
- Comprehensive analysis of MAPK gene family in upland cotton (Gossypium hirsutum) and functional characterization of GhMPK31 in regulating defense response to insect infestation.Plant cell reports · 2024Article
- Activation of MAPK-mediated immunity by phosphatidic acid in response to positive-strand RNA viruses.Plant communications · 2024Article
- Protein Kinase Signaling Pathways in Plant-Frontiers in plant science · 2021Review
- WRKY Transcription Factors inInsects · 2020Article
- Sustained Incompatibility between MAPK Signaling and Pathogen Effectors.International journal of molecular sciences · 2020Review
- Deciphering hydrogen peroxide-induced signalling towards stress tolerance in plants.3 Biotech · 2019Review
- Proteomic characterization of MPK4 signaling network and putative substrates.Plant molecular biology · 2019Article
- Enhanced Nicotiana benthamiana immune responses caused by heterologous plant genes from Pinellia ternata.BMC plant biology · 2018Article
- Gene Profiling in Late Blight Resistance in Potato Genotype SD20.International journal of molecular sciences · 2018Article
- Leptosphaeria maculans Effector Protein AvrLm1 Modulates Plant Immunity by Enhancing MAP Kinase 9 Phosphorylation.iScience · 2018Article
- The Potato MAP3K StVIK Is Required for thePlant physiology · 2018Article
- MAP kinases associate with high molecular weight multiprotein complexes.Journal of experimental botany · 2018Article
- A Pathogen-Responsive Leucine Rich Receptor Like Kinase Contributes toFrontiers in plant science · 2018Article
- A review of redox signaling and the control of MAP kinase pathway in plants.Redox biology · 2017Review
- Characterization, expression patterns and functional analysis of the MAPK and MAPKK genes in watermelon (Citrullus lanatus).BMC plant biology · 2015Article
- WRKY Transcription Factors Phosphorylated by MAPK Regulate a Plant Immune NADPH Oxidase in Nicotiana benthamiana.The Plant cell · 2015Article
- Capsicum annuum transcription factor WRKYa positively regulates defense response upon TMV infection and is a substrate of CaMK1 and CaMK2.Scientific reports · 2015Article
- Redox regulation in plant immune function.Antioxidants & redox signaling · 2014Review
- Article
- Methanol and ethanol modulate responses to danger- and microbe-associated molecular patterns.Frontiers in plant science · 2014Article
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mitogen-activated protein kinase (MAPK) cascades are important signaling modules in eukaryotic cells. They function downstream of sensors/receptors and regulate cellular responses to external and endogenous stimuli. Recent studies demonstrated that SIPK and WIPK, two tobacco (Nicotiana spp.) MAPKs, are involved in signaling plant defense responses to various pathogens. Ntf4, another tobacco MAPK that shares 93.6% and 72.3% identity with SIPK and WIPK, respectively, was reported to be developmentally regulated and function in pollen germination. We found that Ntf4 is also expressed in leaves and suspension-cultured cells. Genomic analysis excluded the possibility that Ntf4 and SIPK are orthologs from the two parental lines of the amphidiploid common tobacco. In vitro and in vivo phosphorylation and activation assays revealed that Ntf4 shares the same upstream MAPK kinase, NtMEK2, with SIPK and WIPK. Similar to SIPK and WIPK, Ntf4 is also stress responsive and can be activated by cryptogein, a proteinaceous elicitin from oomycetic pathogen Phytophthora cryptogea. Tobacco recognition of cryptogein induces rapid hypersensitive response (HR) cell death in tobacco. Transgenic Ntf4 plants with elevated levels of Ntf4 protein showed accelerated HR cell death when treated with cryptogein. In addition, conditional overexpression of Ntf4, which results in high cellular Ntf4 activity, is sufficient to induce HR-like cell death. Based on these results, we concluded that Ntf4 is multifunctional. In addition to its role in pollen germination, Ntf4 is also a component downstream of NtMEK2 in the MAPK cascade that regulates pathogen-induced HR cell death in tobacco.
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