ArticleThe Plant cell2006
A genome-wide survey of R gene polymorphisms in Arabidopsis.
Article in The Plant cell, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 167 papers.
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Who cites it
167 citing papers in PubMed, 347 citations in OpenAlex.
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- Identification of the NBS-LRR gene family and AkNBS-LRR43 and 100 functional analysis under biotic stress.Plant cell reports · 2026Article
- Integrative chromosome-scale genome analysis of cupuassu provides insights into witches' broom disease resistance and expands genomic resources for Theobroma.The plant genome · 2026Article
- Negative Frequency-Dependent Selection Promotes Strain Structure in a Plant Pathogen.Ecology letters · 2026Article
- The glutamate receptor-like GLR2.7 modulates insect egg-induced defense responses in Arabidopsis.The New phytologist · 2025Article
- A major trade-off between growth and defense in Arabidopsis thaliana can vanish in field conditions.PLoS biology · 2025Article
- Evolutionary Systems Biology Identifies Genetic Trade-offs in Rice Defense against Aboveground and Belowground Attackers.Plant & cell physiology · 2025Article
- The resistance awakens: Diversity at the DNA, RNA, and protein levels informs engineering of plant immune receptors from Arabidopsis to crops.The Plant cell · 2025Review
- Patterns of presence-absence variation of NLRs across populations of Solanum chilense are clade-dependent and mainly shaped by past demographic history.The New phytologist · 2025Article
- Navigating Host Immunity and Concurrent Ozone Stress: Strain-Resolved Metagenomics Reveals Maintenance of Intraspecific Diversity and Genetic Variation inEvolutionary applications · 2025Article
- Continental-scale associations of Arabidopsis thaliana phyllosphere members with host genotype and drought.Nature microbiology · 2024Article
- Polymorphism-Aware Models in RevBayes: Species Trees, Disentangling Balancing Selection, and GC-Biased Gene Conversion.Molecular biology and evolution · 2024Article
- High allelic diversity in Arabidopsis NLRs is associated with distinct genomic features.EMBO reports · 2024Article
- Identification and functional characterization of theFrontiers in plant science · 2024Article
- High intraspecies allelic diversity inbioRxiv : the preprint server for biology · 2023Article
- Adaptive evolution in virulence effectors of the rice blast fungus Pyricularia oryzae.PLoS pathogens · 2023Article
- Balancing selection on an MYB transcription factor maintains the twig trichome color variation in Melastoma normale.BMC biology · 2023Article
- Article
- The roles of balancing selection and recombination in the evolution of rattlesnake venom.Nature ecology & evolution · 2022Article
- Profile of Joy M. Bergelson.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
107 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 2 institutions in 1 country.
Funding
Abstract
We used polymorphism analysis to study the evolutionary dynamics of 27 disease resistance (R) genes by resequencing the leucine-rich repeat (LRR) region in 96 Arabidopsis thaliana accessions. We compared single nucleotide polymorphisms (SNPs) in these R genes to an empirical distribution of SNP in the same sample based on 876 fragments selected to sample the entire genome. LRR regions are highly polymorphic for protein variants but not for synonymous changes, suggesting that they generate many alleles maintained for short time periods. Recombination is also relatively common and important for generating protein variants. Although none of the genes is nearly as polymorphic as RPP13, a locus previously shown to have strong signatures of balancing selection, seven genes show weaker indications of balancing selection. Five R genes are relatively invariant, indicating young alleles, but all contain segregating protein variants. Polymorphism analysis in neighboring fragments yielded inconclusive evidence for recent selective sweeps at these loci. In addition, few alleles are candidates for rapid increases in frequency expected under directional selection. Haplotype sharing analysis revealed significant underrepresentation of R gene alleles with extended haplotypes compared with 1102 random genomic fragments. Lack of convincing evidence for directional selection or selective sweeps argues against an arms race driving R gene evolution. Instead, the data support transient or frequency-dependent selection maintaining protein variants at a locus for variable time periods.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.