ArticleProceedings of the National Academy of Sciences of the United States of America2006
Deletion of the neuropeptide Y (NPY) Y1 receptor gene reveals a regulatory role of NPY on catecholamine synthesis and secretion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 56 citations in OpenAlex.
- Structural basis of neuropeptide Y signaling through YMedComm · 2024Article
- Sympathetic NPY controls glucose homeostasis, cold tolerance, and cardiovascular functions in mice.Cell reports · 2024Article
- The abnormalities of adrenomedullary hormonal system in genetic hypertension: Their contribution to altered regulation of blood pressure.Physiological research · 2021Review
- Neuropeptide Y deficiency induces anxiety-like behaviours in zebrafish (Danio rerio).Scientific reports · 2020Article
- Review
- Central Mechanisms of Glucose Sensing and Counterregulation in Defense of Hypoglycemia.Endocrine reviews · 2019Review
- Absence of gut microbial colonization attenuates the sympathoadrenal response to hypoglycemic stress in mice: implications for human neonates.Pediatric research · 2019Article
- Recurrent hypoglycemia inhibits the counterregulatory response by suppressing adrenal activity.The Journal of clinical investigation · 2018Article
- The Proline 7 Substitution in the Preproneuropeptide Y Is Associated with Higher Hepatic Lipase Activity In Vivo.International journal of endocrinology · 2017Article
- Article
- Fasting induces a form of autonomic synaptic plasticity that prevents hypoglycemia.Proceedings of the National Academy of Sciences of the United States of America · 2016Article
- Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue.Scientific reports · 2015Article
- Article
- Neuropeptide y gates a stress-induced, long-lasting plasticity in the sympathetic nervous system.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2013Article
- Stress-induced changes in adrenal neuropeptide Y expression are regulated by a negative feedback loop.Journal of neurochemistry · 2013Article
- Article
- Neuropeptide Y in the noradrenergic neurons induces the development of cardiometabolic diseases in a transgenic mouse model.Indian journal of endocrinology and metabolism · 2012Article
- A role for neuropeptide Y in the gender-specific gastrointestinal, corticosterone and feeding responses to stress.British journal of pharmacology · 2012Article
- Expression of trophic peptides and their receptors in chromaffin cells and pheochromocytoma.Cellular and molecular neurobiology · 2010Review
- Kinetic study of neuropeptide Y (NPY) proteolysis in blood and identification of NPY3-35: a new peptide generated by plasma kallikrein.The Journal of biological chemistry · 2009Article
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Authors and funding
12 authors at 6 institutions in 4 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The contribution of neuropeptide Y (NPY), deriving from adrenal medulla, to the adrenosympathetic tone is unknown. We found that in response to NPY, primary cultures of mouse adrenal chromaffin cells secreted catecholamine, and that this effect was abolished in cultures from NPY Y(1) receptor knockout mice (Y(1)-/-). Compared with wild-type mice (Y(1)+/+), the adrenal content and constitutive release of catecholamine were increased in chromaffin cells from Y(1)-/- mice. In resting animals, catecholamine plasma concentrations were higher in Y(1)-/- mice. Comparing the adrenal glands of both genotypes, no differences were observed in the area of the medulla, cortex, and X zone. The high turnover of adrenal catecholamine in Y(1)-/- mice was explained by the enhancement of tyrosine hydroxylase (TH) activity, although no change in the affinity of the enzyme was observed. The molecular interaction between the Y(1) receptor and TH was demonstrated by the fact that NPY markedly inhibited the forskolin-induced luciferin activity in Y(1) receptor-expressing SK-N-MC cells transfected with a TH promoter sequence. We propose that NPY controls the release and synthesis of catecholamine from the adrenal medulla and consequently contributes to the sympathoadrenal tone.
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