ArticleJournal of dental research2006
Omega-3 fatty acid effect on alveolar bone loss in rats.
Article in Journal of dental research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 102 citations in OpenAlex.
- The Impact of Omega-3 Supplements on Non-Surgical Periodontal Therapy: A Systematic Review.Nutrients · 2022Pooled it
- Nonsurgical Treatment of Periodontitis in Menopausal Patients: A Randomized Control Trial.BioMed research international · 2024Trial
- Arachidonic acid in aging: New roles for old players.Journal of advanced research · 2025Review
- Physical exercise alone or combined with omega-3 modulates apical periodontitis induced in rats.Scientific reports · 2025Article
- A diet rich in omega-3 fatty acid improves periodontitis and tissue destruction by MMP2- and MMP9-linked inflammation in a murine model.Odontology · 2024Article
- Omega-3 Effects on Ligature-Induced Periodontitis in Rats with Fructose-Induced Metabolic Syndrome.Inflammation · 2023Article
- Impact of health and lifestyle food supplements on periodontal tissues and health.Periodontology 2000 · 2022Review
- Alterations in bone metabolites with age in C57BL/6 mice model.Biogerontology · 2022Article
- Protective Effect of Virgin Coconut Oil on Osteopenia Induced by High Refined Carbohydrate-Containing Diet in Mice.Foods (Basel, Switzerland) · 2022Article
- Docosahexaenoic acid inhibits TNF-α-induced osteoclast formation and orthodontic tooth movement through GPR120.Frontiers in immunology · 2022Article
- Docosahexaenoic Acid Inhibits Inflammation-Induced Osteoclast Formation and Bone ResorptionFrontiers in endocrinology · 2019Article
- Evaluation of the Effects of Three Plant Species (Journal of dentistry (Shiraz, Iran) · 2017Article
- Long-term evaluation of oral gavage with periodontopathogens or ligature induction of experimental periodontal disease in mice.Clinical oral investigations · 2016Article
- Therapeutic Targets for Management of Periodontitis and Diabetes.Current pharmaceutical design · 2016Review
- Oxidative Stress and Dietary Fat Type in Relation to Periodontal Disease.Antioxidants (Basel, Switzerland) · 2015Review
- Investigation of anodized titanium implants coated with triterpenoids extracted from black cohosh: an animal study.The journal of advanced prosthodontics · 2014Article
- Endogenous n-3 polyunsaturated fatty acids (PUFAs) mitigate ovariectomy-induced bone loss by attenuating bone marrow adipogenesis in FAT1 transgenic mice.Drug design, development and therapy · 2013Article
- The effects of n-3 fatty acids on inflammatory cytokines in osteoporotic spinal cord injured patients: A randomized clinical trial.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2012Article
- Role of Porphyromonas gingivalis phosphoserine phosphatase enzyme SerB in inflammation, immune response, and induction of alveolar bone resorption in rats.Infection and immunity · 2010Article
- Porphyromonas gingivalis and Treponema denticola Mixed Microbial Infection in a Rat Model of Periodontal Disease.Interdisciplinary perspectives on infectious diseases · 2010Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
Gingival inflammation and alveolar bone resorption are hallmarks of adult periodontitis, elicited in response to oral micro-organisms such as Porphyromonas gingivalis. We hypothesized that omega (omega)-3 fatty acids (FA) dietary supplementation would modulate inflammatory reactions leading to periodontal disease in infected rats. Rats were fed fish oil (omega-3 FA) or corn oil (n-6 FA) diets for 22 weeks and were infected with P. gingivalis. Rats on the omega-3 FA diet exhibited elevated serum levels of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), documenting diet-induced changes. PCR analyses demonstrated that rats were orally colonized by P. gingivalis; increased IgG antibody levels substantiated this infection. P. gingivalis-infected rats treated with omega-3 FA had significantly less alveolar bone resorption. These results demonstrated the effectiveness of an omega-3 FA-supplemented diet in modulating alveolar bone resorption following P. gingivalis infection, and supported that omega-3 FA may be a useful adjunct in the treatment of periodontal disease.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.