ArticleBiophysical journal2006
Structured water layers adjacent to biological membranes.
Article in Biophysical journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Cantilever-based optical interfacial force microscope in liquid using photothermal actuation.The Review of scientific instruments · 2025Article
- Tip treatment for subnanoscale atomic force microscopy in liquid by atomic layer deposition Al2O3 coating.Microscopy (Oxford, England) · 2025Article
- Exploring the influence of water micro assemblies on protein folding, enzyme catalysis and membrane dynamics.European biophysics journal : EBJ · 2025Review
- Atomic-scale structure of interfacial water on gel and liquid phase lipid membranes.Faraday discussions · 2024Article
- When Phased without Water: Biophysics of Cellular Desiccation, from Biomolecules to Condensates.Chemical reviews · 2023Review
- Predicting the placement of biomolecular structures on AFM substrates based on electrostatic interactions.Frontiers in molecular biosciences · 2023Article
- Particle-based hematite crystallization is invariant to initial particle morphology.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Signaling in the crowded cell.Current opinion in structural biology · 2021Review
- Genomes of Thaumarchaeota from deep sea sediments reveal specific adaptations of three independently evolved lineages.The ISME journal · 2021Article
- Water at charged interfaces.Nature reviews. Chemistry · 2021Review
- PI3K Driver Mutations: A Biophysical Membrane-Centric Perspective.Cancer research · 2021Review
- Why Proteins are Big: Length Scale Effects on Equilibria and Kinetics.The protein journal · 2019Review
- Magnetic control of graphitic microparticles in aqueous solutions.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Sub-nanometer Resolution Imaging with Amplitude-modulation Atomic Force Microscopy in Liquid.Journal of visualized experiments : JoVE · 2016Article
- Accurate, explicit formulae for higher harmonic force spectroscopy by frequency modulation-AFM.Beilstein journal of nanotechnology · 2015Article
- Multiparametric high-resolution imaging of native proteins by force-distance curve-based AFM.Nature protocols · 2014Article
- Structure and permeability of ion-channels by integrated AFM and waveguide TIRF microscopy.Scientific reports · 2014Article
- Resolving structure and mechanical properties at the nanoscale of viruses with frequency modulation atomic force microscopy.PloS one · 2012Article
- Submolecular-scale imaging of α-helices and C-terminal domains of tubulins by frequency modulation atomic force microscopy in liquid.Biophysical journal · 2011Article
- The self-organizing fractal theory as a universal discovery method: the phenomenon of life.Theoretical biology & medical modelling · 2011Article
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Water amid the restricted space of crowded biological macromolecules and at membrane interfaces is essential for cell function, though the structure and function of this "biological water" itself remains poorly defined. The force required to remove strongly bound water is referred to as the hydration force and due to its widespread importance, it has been studied in numerous systems. Here, by using a highly sensitive dynamic atomic force microscope technique in conjunction with a carbon nanotube probe, we reveal a hydration force with an oscillatory profile that reflects the removal of up to five structured water layers from between the probe and biological membrane surface. Further, we find that the hydration force can be modified by changing the membrane fluidity. For 1,2-dipalmitoyl-sn-glycero-3-phosphocholine gel (Lbeta) phase bilayers, each oscillation in the force profile indicates the force required to displace a single layer of water molecules from between the probe and bilayer. In contrast, 1,2-dipalmitoyl-sn-glycero-3-phosphocholine fluid (Lalpha) phase bilayers at 60 degrees C and 1,2-dioleoyl-sn-glycero-3-phosphocholine fluid (Lalpha) phase bilayers at 24 degrees C seriously disrupt the molecular ordering of the water and result predominantly in a monotonic force profile.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.