ArticleThe Annals of thoracic surgery2006
Age- and gender-related differences in ischemia/reperfusion injury and cardioprotection: effects of diazoxide.
Article in The Annals of thoracic surgery, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 65 citations in OpenAlex.
- Differential Effects of Reperfusion on Cardiac Mitochondrial Subpopulations in a Preclinical Porcine Model of Acute Myocardial Infarction.Frontiers in cell and developmental biology · 2022Article
- Clocks, Rhythms, Sex, and Hearts: How Disrupted Circadian Rhythms, Time-of-Day, and Sex Influence Cardiovascular Health.Biomolecules · 2021Review
- Phosphoproteomic analysis identifies phospho-Threonine-17 site of phospholamban important in low molecular weight isoform of fibroblast growth factor 2-induced protection against post-ischemic cardiac dysfunction.Journal of molecular and cellular cardiology · 2020Article
- Expression of mitochondrial membrane-linked SAB determines severity of sex-dependent acute liver injury.The Journal of clinical investigation · 2019Article
- Article
- Effects of Cardiovascular Risk Factors on Cardiac STAT3.International journal of molecular sciences · 2018Review
- Mitochondrial transplantation: applications for pediatric patients with congenital heart disease.Translational pediatrics · 2018Review
- Alpha Lipoic Acid: A Therapeutic Strategy that Tend to Limit the Action of Free Radicals in Transplantation.International journal of molecular sciences · 2018Review
- Attenuated recovery of contractile function in aging hearts following global ischemia/reperfusion: Role of extracellular HSP27 and TLR4.Molecular medicine (Cambridge, Mass.) · 2017Article
- The AMPK Activator Aicar Ameliorates Age-Dependent Myocardial Injury in Murine Hemorrhagic Shock.Shock (Augusta, Ga.) · 2017Article
- Mitochondria in the middle: exercise preconditioning protection of striated muscle.The Journal of physiology · 2016Review
- Mitochondrial transplantation for therapeutic use.Clinical and translational medicine · 2016Review
- Cardiovascular KPathobiology of aging & age related diseases · 2016Review
- Potassium-induced conversion of ventricular fibrillation after aortic declamping.Interactive cardiovascular and thoracic surgery · 2013Article
- Hyperkalemic cardioplegia for adult and pediatric surgery: end of an era?Frontiers in physiology · 2013Review
- Age-associated differences in gene expression in response to delayed anesthetic preconditioning.Age (Dordrecht, Netherlands) · 2012Article
- Microarray and proteomic analysis of the cardioprotective effects of cold blood cardioplegia in the mature and aged male and female.Physiological genomics · 2012Article
- Opposing effects of age and calorie restriction on molecular determinants of myocardial ischemic tolerance.Rejuvenation research · 2012Article
- Age and ovariectomy abolish beneficial effects of female sex on rat ventricular myocytes exposed to simulated ischemia and reperfusion.PloS one · 2012Article
- Injection of isolated mitochondria during early reperfusion for cardioprotection.American journal of physiology. Heart and circulatory physiology · 2009Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
backgroundRecent studies have demonstrated that aging is associated with reduced tolerance to ischemia and that the aged (not senescent) female heart has greater susceptibility to ischemia as compared with the aged male heart. Previously, we have shown that ischemia can be modulated with cardioplegia in the male heart; however, efficacy in the female heart was unknown.
methodsIn this study, male and female mature (15 to 20 weeks) aged (>32 months) rabbit hearts (n = 134) were subjected to Langendorff perfusion. Control hearts were perfused for 180 minutes. Global ischemia hearts received 30 minutes of equilibrium, 30 minutes of global ischemia, and 120 minutes of reperfusion. Cardioplegia +/- diazoxide was infused separately, 5 minutes before global ischemia.
resultsGlobal ischemia significantly decreased postischemic functional recovery and significantly increased infarct size in the mature and aged male and female heart (p < 0.05 versus control). The effects of global ischemia were significantly exacerbated (p < 0.05) in the aged heart as compared with the mature heart. Cardioplegia +/- diazoxide significantly increased postischemic functional recovery and significantly decreased infarct size in mature male and female hearts, but these effects were significantly decreased in the aged heart (p < 0.05) and in the aged female as compared with the aged male heart.
conclusionsPostischemic functional recovery and infarct size are affected by age but not by gender. The cardioprotection afforded by cardioplegia is affected by age and gender with a strong age-by-gender interaction for end-diastolic pressure and infarct size. Our results indicate that currently optimized cardioplegia protocols effective in the male heart are not as efficacious in the aged female heart.
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