Evidence map›Paper›PMID 16797254›Full record

ReviewDNA repair2006

Chromosomal translocations involving the MLL gene: molecular mechanisms.

Peter D Aplan

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in DNA repair, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
2.8field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 67 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Article
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. The cellular etiology of chromosome translocations.Current opinion in cell biology · 2013
    Review
  15. Article
  16. Article
  17. Disordered epigenetic regulation in MLL-related leukemia.International journal of hematology · 2012
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

1 author at 1 institution in 1 country.

Peter D AplanGenetics Branch, Center for Cancer Research, National Cancer Institute, National Institutes of Health, National Naval Medical Center, Bldg. 8 Rm. 5101, 8901 Rockville Pike, Bethesda, MD 20889, USA. aplanp@mail.nih.gov
Center for Cancer Research · US

Funding

Mutation Mechanisms Leading to Malignant Transformation, Including Chromosomal Translocation and Point MutationsZIASC010379 · NCI · DIVISION OF CLINICAL SCIENCES - NCI · PI APLAN, PETER · 2009 to 2025
$4.9M
Mechanisms of Chromosomal TranslocationZ01SC010379 · SC · DIVISION OF CLINICAL SCIENCES - NCI · PI APLAN, PETER D · 2001 to 2008
$933k
Intramural NIH HHS
6 · The paper itself

Abstract

A wide array of recurrent, non-random chromosomal translocations are associated with hematologic malignancies; experimental models have clearly demonstrated that many of these translocations are causal events during malignant transformation. Translocations involving the MLL gene are among the most common of these non-random translocations. Leukemias with MLL translocations have been the topic of intense interest because of the unusual, biphenotypic immunophenotype of these leukemias, because of the unique clinical presentation of some MLL translocations (infant leukemia and therapy-related leukemia), and because of the large number of different chromosomal loci that partner with MLL in these translocations. This review is focused on the potential mechanisms that lead to MLL translocations, and will discuss aberrant VDJ recombination, Alu-mediated recombination, non-homologous end joining, as well as the effect of DNA topoisomerase II poisons and chromatin structure.

Indexed as

Topoisomerase II InhibitorsTranslocation, GeneticBase SequenceChromatinHistone-Lysine N-MethyltransferaseHumansInfantLeukemia, Myeloid, AcuteModels, GeneticMolecular Sequence DataMyeloid-Lymphoid Leukemia ProteinRecombination, GeneticChromatinHistone-Lysine N-MethyltransferaseKMT2A protein, humanMyeloid-Lymphoid Leukemia ProteinTopoisomerase II Inhibitors

Identifiers

PMID16797254
PMCPMC1635494
OpenAlexW1981069958

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.