ArticleMicrobes and infection2006
Signature patterns revealed by microarray analyses of mice infected with influenza virus A and Streptococcus pneumoniae.
Article in Microbes and infection, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 22 citations in OpenAlex.
- Immune-adaptive pathogen variation reveals targetable mediators of gram-positive bacterial killing in macrophages.Science advances · 2026Article
- An efficient method for mining cross-timepoint gene regulation sequential patterns from time course gene expression datasets.BMC bioinformatics · 2013Article
- Gene expression-based classifiers identify Staphylococcus aureus infection in mice and humans.PloS one · 2013Article
- Microwave and magnetic (M(2) ) proteomics of the experimental autoimmune encephalomyelitis animal model of multiple sclerosis.Electrophoresis · 2012Article
- Global transcriptome analysis in influenza-infected mouse lungs reveals the kinetics of innate and adaptive host immune responses.PloS one · 2012Article
- The innate immune response to Streptococcus pneumoniae in the lung depends on serotype and host response.Vaccine · 2011Article
- Uncovering the global host cell requirements for influenza virus replication via RNAi screening.Microbes and infection · 2011Review
- Gene expression signature-based screening identifies new broadly effective influenza a antivirals.PloS one · 2010Article
- HLA class I molecules reflect an altered host proteome after influenza virus infection.Human immunology · 2010Article
- Multiple pathways in prevention of immune-mediated brain disorders: Implications for the prevention of autism.Journal of neuroimmunology · 2009Article
- Gene expression analysis of host innate immune responses during Lethal H5N1 infection in ferrets.Journal of virology · 2008Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
Abstract
We used cDNA microarrays to identify differentially expressed genes in mice in response to infections with influenza virus A/PR/8/34 (H1N1) and Streptococcus pneumoniae. Expression microarray analysis showed up-regulation and down-regulation of many genes involved in the defense, inflammatory response and intracellular signaling pathways including chemokine, apoptosis, MAPK, Notch, Jak-STAT, T-cell receptor and complement and coagulation cascades. We have revealed signature patterns of gene expression in mice infected with two different classes of pathogens: influenza virus A and S. pneumoniae. Quantitative real-time RT-PCR results confirmed microarray results for most of the genes tested. These studies document clear differences in gene expression profiles between mice infected with influenza virus A and S. pneumoniae. Identification of genes that are differentially expressed after respiratory infections can provide insights into the mechanisms by which the host interacts with different pathogens, useful information about stage of diseases and selection of suitable targets for early diagnosis and treatments. The advantage of this novel approach is that the detection of pathogens is based on the differences in host gene expression profiles in response to different pathogens instead of detecting pathogens directly.
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Registered trials
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