ReviewJournal of cellular and molecular medicine
The story of cell secretion: events leading to the discovery of the 'porosome' - the universal secretory machinery in cells.
Review in Journal of cellular and molecular medicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- Detection of Matrix Metalloproteinase Activity by Bioluminescence via Intein-Mediated Biotinylation of Luciferase.Sensors (Basel, Switzerland) · 2018Article
- The neuronal porosome complex in health and disease.Experimental biology and medicine (Maywood, N.J.) · 2016Review
- Porosome in the Exocrine Pancreas: A Detailed EM Study suppressor.Discoveries (Craiova, Romania) · 2014Article
- 3D organization and function of the cell: Golgi budding and vesicle biogenesis to docking at the porosome complex.Histochemistry and cell biology · 2012Article
- Porosome: the secretory portal in cells.Biochemistry · 2009Review
- Cell secretion: an update.Journal of cellular and molecular medicine · 2008Review
- Cell secretion - finally sees the light.Journal of cellular and molecular medicineArticle
- Role of aquaporins and regulation of secretory vesicle volume in cell secretion.Journal of cellular and molecular medicineReview
- Landmark discoveries in intracellular transport and secretion.Journal of cellular and molecular medicineReview
- Cellular secretion studied by force microscopy.Journal of cellular and molecular medicineReview
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Abstract
Cell secretion has come of age, and a century old quest has been elegantly solved. We have come a long way since earlier observations of what appeared to be 'fibrillar regions' at the cell plasma membrane, and electrophysiological studies suggesting the presence of 'fusion pores' at the cell plasma membrane where secretion occurs. Finally, the fusion pore or 'porosome' has been discovered, and its morphology and dynamics determined at nm resolution and in real time in live secretory cells. The porosome has been isolated, its composition determined and it has been both structurally and functionally reconstituted in artificial lipid membrane. The discovery of the porosome as the universal secretory machinery in cells and the discovery of the molecular mechanism of vesicular content expulsion during cell secretion have finally enabled a clear understanding of this important cellular process. This review outlines the fascinating and exciting journey leading to the discovery of the porosome, ultimately solving one of the most difficult, significant, and fundamental cellular process -cell secretion.
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