ArticleAIDS research and human retroviruses2006
Longitudinal assessment of de novo T cell production in relation to HIV-associated T cell homeostasis failure.
Article in AIDS research and human retroviruses, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Delaying a treatment switch in antiretroviral-treated HIV type 1-infected patients with detectable drug-resistant viremia does not have a profound effect on immune parameters: AIDS Clinical Trials Group Study A5115.AIDS research and human retroviruses · 2009Trial
- Accelerated disease progression and robust innate host response in aged SIVmac239-infected Chinese rhesus macaques is associated with enhanced immunosenescence.Scientific reports · 2017Article
- Brief Report: Role of Thymic Reconstitution in the Outcome of AIDS-Related PML.Journal of acquired immune deficiency syndromes (1999) · 2015Article
- Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease.The Journal of infectious diseases · 2014Article
- Late-emerging strains of HIV induce T-cell homeostasis failure by promoting bystander cell death and immune exhaustion in naïve CD4 and all CD8 T-cells.Medical hypotheses · 2014Article
- Article
- Acute HIV-1 seroconversion with an unusual plasma biomarker profile.Clinical and vaccine immunology : CVI · 2013Article
- Value of a quality assessment program in optimizing cryopreservation of peripheral blood mononuclear cells in a multicenter study.Clinical and vaccine immunology : CVI · 2013Article
- The dual impact of HIV-1 infection and aging on naïve CD4 T-cells: additive and distinct patterns of impairment.PloS one · 2011Article
- A challenge for the future: aging and HIV infection.Immunologic research · 2010Review
- Good cell, bad cell: flow cytometry reveals T-cell subsets important in HIV disease.Cytometry. Part A : the journal of the International Society for Analytical Cytology · 2010Review
- Correlation of immune activation with HIV-1 RNA levels assayed by real-time RT-PCR in HIV-1 subtype C infected patients in Northern India.Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology · 2007Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Loss of circulating CD4+ T cells in HIV-1 disease is balanced by CD8+ lymphocytosis to maintain normal CD3+ T cell counts [blind T cell homeostasis (TCH)]. However, for unknown reasons TCH generally fails 1.5-2.5 years before clinically defined AIDS. We investigated whether TCH failure was associated with changes in thymic production of T cells. Using specimens stored prospectively in the Multicenter AIDS Cohort Study (MACS), we measured expression of signal-joint T cell receptor excision circles (sjTRECs), a marker for thymic T cell production, and the fraction of proliferating naive and memory T cells during a 6-8 year period bracketing TCH failure. Segmented regression modeling assessed (1) rates of change in TREC levels before and after TCH failure, and (2) whether these were affected by cellular proliferation, which may dilute sjTREC levels. TCH failure was associated with a large decline in sjTREC (median 1109-fold, p = 0.028); the rate of this decline was only slightly affected when increased proliferation of naive T cells or other peripheral lymphocytes was taken into account. Preferential loss of naive CD4+ T cells was also noted before TCH failure, as has been seen in other studies. These results suggest that deficits in de novo T cell production, either through the decline of thymic function or the destruction of naive T cells, are likely to play an important role in TCH failure and progression of HIV-1 disease.
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