ReviewThe AAPS journal2006
Brain tissue lipidomics: direct probing using matrix-assisted laser desorption/ionization mass spectrometry.
Review in The AAPS journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 46 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
46 citing papers in PubMed, 123 citations in OpenAlex.
- New Analytical Technologies to Resolve, Interpret, and Understand Lipid Complexity.Annual review of analytical chemistry (Palo Alto, Calif.) · 2026Review
- Phenotypic Physiological and Metabolomic Analyses Reveal Crucial Metabolic Pathways in Quinoa (International journal of molecular sciences · 2025Article
- Seeing is Believing: Developing Multimodal Metabolic Insights at the Molecular Level.ACS central science · 2024Review
- Oxidative stress: The nexus of obesity and cognitive dysfunction in diabetes.Frontiers in endocrinology · 2023Review
- Tissue fixation effects on human retinal lipid analysis by MALDI imaging and LC-MS/MS technologies.Journal of mass spectrometry : JMS · 2021Article
- Applications of stable isotopes in MALDI imaging: current approaches and an eye on the future.Analytical and bioanalytical chemistry · 2021Review
- Streamlined Analysis of Cardiolipins in Prokaryotic and Eukaryotic Samples Using a Norharmane Matrix by MALDI-MSI.Journal of the American Society for Mass Spectrometry · 2020Article
- Lipid Analysis of 30 000 Individual Rodent Cerebellar Cells Using High-Resolution Mass Spectrometry.Analytical chemistry · 2019Article
- Charting the unexplored extracellular matrix in cancer.International journal of experimental pathology · 2018Review
- Mass spectrometry imaging of rat brain lipid profile changes over time following traumatic brain injury.Journal of neuroscience methods · 2016Article
- Food-induced changes of lipids in rat neuronal tissue visualized by ToF-SIMS imaging.Scientific reports · 2016Article
- Intact lipid imaging of mouse brain samples: MALDI, nanoparticle-laser desorption ionization, and 40 keV argon cluster secondary ion mass spectrometry.Analytical and bioanalytical chemistry · 2016Article
- Dietary DHA supplementation causes selective changes in phospholipids from different brain regions in both wild type mice and the Tg2576 mouse model of Alzheimer's disease.Biochimica et biophysica acta · 2016Article
- Diagnosis of inflammatory bowel disease: Potential role of molecular biometrics.World journal of gastrointestinal surgery · 2014Review
- Dithranol as a matrix for matrix assisted laser desorption/ionization imaging on a fourier transform ion cyclotron resonance mass spectrometer.Journal of visualized experiments : JoVE · 2013Article
- Accumulated phosphatidylcholine (16:0/16:1) in human colorectal cancer; possible involvement of LPCAT4.Cancer science · 2013Article
- Current status and future perspectives of mass spectrometry imaging.International journal of molecular sciences · 2013Review
- High energy collisions on tandem time-of-flight mass spectrometers.Journal of the American Society for Mass Spectrometry · 2013Article
- Imaging beyond the proteome.Chemical communications (Cambridge, England) · 2012Review
- Lipid imaging with time-of-flight secondary ion mass spectrometry (ToF-SIMS).Biochimica et biophysica acta · 2011Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Lipidomics is the new frontier in biomolecular structural studies. Not only are lipids the main components in membranes that define the contours of the cell and its organelles, but they are also used for storage. Lipids form stable noncovalent complexes with proteins as well as with many drugs. Lipids are a storage depot for drugs and certain types of organic molecules. To study lipid composition and distribution, complex and time-consuming techniques are used. However, recent advances in mass spectrometry, mainly matrix-assisted laser desorption/ionization (MALDI) have made it possible to directly probe tissues to study structural components, as well as for the localization of drugs. Direct tissue imaging is a powerful tool as it gives a more complete and accurate structural picture and can trace and follow where drugs localize in tissue with minimal anatomical disruption and a minimum of manipulations. Hence, we believe that in addition to its accuracy and efficiency, this new approach will lead to a better understanding of physiological processes as well as the pathophysiology of disease.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.