ReviewThe AAPS journal2006
Modulating inhibitory ligand-gated ion channels.
Review in The AAPS journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 23 citations in OpenAlex.
- Emerging pharmacological targets in overactive bladder therapy: experimental and clinical evidences.International urogynecology journal and pelvic floor dysfunction · 2008Pooled it
- Glutamate-gated chloride channel subunit cDNA sequencing of Cochliomyia hominivorax (Diptera: Calliphoridae): cDNA variants and polymorphisms.Invertebrate neuroscience : IN · 2014Article
- Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites.Structure (London, England : 1993) · 2013Article
- Receptor targets of amacrine cells.Visual neuroscience · 2012Review
- Microsecond simulations indicate that ethanol binds between subunits and could stabilize an open-state model of a glycine receptor.Biophysical journal · 2011Article
- Taurine regulation of short term synaptic plasticity in fragile X mice.Journal of biomedical science · 2010Article
- Interaction of androsterone and progesterone with inhibitory ligand-gated ion channels: a patch clamp study.Naunyn-Schmiedeberg's archives of pharmacology · 2009Article
- Chloride channels as drug targets.Nature reviews. Drug discovery · 2009Review
- Stoichiometric pore mutations of the GABAAR reveal a pattern of hydrogen bonding with picrotoxin.Biophysical journal · 2008Article
- Ionotropic glutamate receptors & CNS disorders.CNS & neurological disorders drug targets · 2008Review
- The cys-loop ligand-gated ion channel gene superfamily of the red flour beetle, Tribolium castaneum.BMC genomics · 2007Article
- Ion channel pharmacology.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2007Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The glycine and gamma-aminobutyric acid receptors (GlyR and GABA(A)R, respectively) are the major inhibitory neurotransmitter-gated receptors in the central nervous system of animals. Given the important role of these receptors in neuronal inhibition, they are prime targets of many therapeutic agents and are the object of intense studies aimed at correlating their structure and function. In this review, the structure and dynamics of these and other homologous members of the nicotinicoid superfamily are described. The modulatory actions of the major biological macromolecules that bind and allosterically affect these receptors are also discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.