ReviewThe AAPS journal2006
Computational methods in drug design: modeling G protein-coupled receptor monomers, dimers, and oligomers.
Review in The AAPS journal, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
22 citing papers in PubMed, 52 citations in OpenAlex.
- Computational Methods to Target Protein-Protein Interactions.Methods in molecular biology (Clifton, N.J.) · 2024Article
- GPR6 Structural Insights: Homology Model Construction and Docking Studies.Molecules (Basel, Switzerland) · 2020Article
- Towards A Molecular Understanding of The Cannabinoid Related Orphan Receptor GPR18: A Focus on Its Constitutive Activity.International journal of molecular sciences · 2019Article
- Methods used to study the oligomeric structure of G-protein-coupled receptors.Bioscience reports · 2017Review
- Apelin receptor homodimer-oligomers revealed by single-molecule imaging and novel G protein-dependent signaling.Scientific reports · 2017Article
- Methods for the Development of In Silico GPCR Models.Methods in enzymology · 2017Article
- Chromenopyrazole, a Versatile Cannabinoid Scaffold with in Vivo Activity in a Model of Multiple Sclerosis.Journal of medicinal chemistry · 2016Article
- Difference and Influence of Inactive and Active States of Cannabinoid Receptor Subtype CB2: From Conformation to Drug Discovery.Journal of chemical information and modeling · 2016Article
- Computational approaches for modeling GPCR dimerization.Current pharmaceutical biotechnology · 2014Review
- Article
- Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists.Science (New York, N.Y.) · 2010Article
- A lipid pathway for ligand binding is necessary for a cannabinoid G protein-coupled receptor.The Journal of biological chemistry · 2010Article
- Increasingly accurate dynamic molecular models of G-protein coupled receptor oligomers: Panacea or Pandora's box for novel drug discovery?Life sciences · 2010Review
- Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the protean effects of "selective" antagonists.The Journal of biological chemistry · 2009Article
- Computational molecular biology approaches to ligand-target interactions.HFSP journal · 2009Article
- Structural biology of human cannabinoid receptor-2 helix 6 in membrane-mimetic environments.Biochemical and biophysical research communications · 2009Article
- Solid-state NMR and molecular dynamics characterization of cannabinoid receptor-1 (CB1) helix 7 conformational plasticity in model membranes.Biochimica et biophysica acta · 2009Article
- Ligand-binding architecture of human CB2 cannabinoid receptor: evidence for receptor subtype-specific binding motif and modeling GPCR activation.Chemistry & biology · 2008Article
- Advances in the Development and Application of Computational Methodologies for Structural Modeling of G-Protein Coupled Receptors.Expert opinion on drug discovery · 2008Article
- Analysis of the activation mechanism of the guinea-pig Histamine H1-receptor.Journal of computer-aided molecular design · 2007Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
Abstract
G protein-coupled receptors (GPCRs) are membrane proteins that serve as very important links through which cellular signal transduction mechanisms are activated. Many vital physiological events such as sensory perception, immune defense, cell communication, chemotaxis, and neurotransmission are mediated by GPCRs. Not surprisingly, GPCRs are major targets for drug development today. Most modeling studies in the GPCR field have focused upon the creation of a model of a single GPCR (ie, a GPCR monomer) based upon the crystal structure of the Class A GPCR, rhodopsin. However, the emerging concept of GPCR dimerization has challenged our notions of the monomeric GPCR as functional unit. Recent work has shown not only that many GPCRs exist as homo- and heterodimers but also that GPCR oligomeric assembly may have important functional roles. This review focuses first on methodology for the creation of monomeric GPCR models. Special emphasis is given to the identification of localized regions where the structure of a GPCR may diverge from that of bovine rhodopsin. The review then focuses on GPCR dimers and oligomers and the bioinformatics methods available for identifying homo- and heterodimer interfaces.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.