ArticleNeurochemical research2006
H2O2 mobilizes Ca2+ from agonist- and thapsigargin-sensitive and insensitive intracellular stores and stimulates glutamate secretion in rat hippocampal astrocytes.
Article in Neurochemical research, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 39 citations in OpenAlex.
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- Luteolin Alleviates Oxidative Stress in Chronic Obstructive Pulmonary Disease Induced by Cigarette Smoke via Modulation of the TRPV1 and CYP2A13/NRF2 Signaling Pathways.International journal of molecular sciences · 2023Article
- Antioxidant potential of nanomaterials.Turkish journal of biology = Turk biyoloji dergisi · 2023Review
- TRP Channels in Respiratory Pathophysiology: the Role of Oxidative, Chemical Irritant and Temperature Stimuli.Current neuropharmacology · 2015Review
- Repeated administration of PEP-1-Cu,Zn-superoxide dismutase and PEP-1-peroxiredoxin-2 to senescent mice induced by D-galactose improves the hippocampal functions.Neurochemical research · 2013Article
- Effects of antiepileptic drugs on antioxidant and oxidant molecular pathways: focus on trace elements.Cellular and molecular neurobiology · 2013Review
- Ebselen alters mitochondrial physiology and reduces viability of rat hippocampal astrocytes.DNA and cell biology · 2013Article
- Advanced glycation end products acutely impair ca(2+) signaling in bovine aortic endothelial cells.Frontiers in physiology · 2013Article
- Effects of hydrogen peroxide on diazepam and xylazine sedation in chicks.Interdisciplinary toxicology · 2012Article
- Influence of viral vector-mediated delivery of superoxide dismutase and catalase to the hippocampus on spatial learning and memory during aging.Antioxidants & redox signaling · 2012Article
- Dopamine induces Ca2+ signaling in astrocytes through reactive oxygen species generated by monoamine oxidase.The Journal of biological chemistry · 2010Article
- H(2)O(2)-mediated modulation of cytosolic signaling and organelle function in rat hippocampus.Pflugers Archiv : European journal of physiology · 2009Article
- Differential effects of methionine and cysteine oxidation on [Ca2+] i in cultured hippocampal neurons.Cellular and molecular neurobiology · 2009Article
- Hydrogen peroxide inhibits Ca2+-dependent chloride secretion across colonic epithelial cells via distinct kinase signaling pathways and ion transport proteins.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2008Article
- H2O 2-stimulated Ca2+ influx via TRPM2 is not the sole determinant of subsequent cell death.Pflugers Archiv : European journal of physiology · 2008Article
- Protective effects of resveratrol on hydrogen peroxide induced toxicity in primary cortical astrocyte cultures.Neurochemical research · 2008Article
- Mechanisms of glutamate release from astrocytes.Neurochemistry international · 2008Review
- Review
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The effect of hydrogen peroxide (H2O2) on cytosolic free calcium concentration ([Ca2+]c) as well as its effect on glutamate secretion in rat hippocampal astrocytes have been the aim of the present research. Our results show that 100 microM H2O2 induces an increase in [Ca2+]c, that remains at an elevated level while the oxidant is present in the perfusion medium, due to its release from intracellular stores as it was observed in the absence of extracellular Ca2+, followed by a significant increase in glutamate secretion. Ca2+-mobilization in response to the oxidant could only be reduced by thapsigargin plus FCCP, indicating that the Ca2+-mobilizable pool by H2O2 includes both endoplasmic reticulum and mitochondria. We conclude that ROS in hippocampal astrocytes might contribute to an elevation of resting [Ca2+]c which, in turn, could lead to a maintained secretion of the excitatory neurotransmitter glutamate, which has been considered a situation potentially leading to neurotoxicity in the hippocampus.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.