SynthesisDer Orthopade2006
[Diagnostic strategies in cases of suspected periprosthetic infection of the knee. A review of the literature and current recommendations].
Synthesis in Der Orthopade, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 31 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
31 citing papers in PubMed.
- Two-stage cementless revision of infected hip endoprostheses.Clinical orthopaedics and related research · 2009Trial
- [Ligament instability in total knee arthroplasty--causal analysis].Der Orthopade · 2007Trial
- Knee arthrodesis with intramedullary nail in end-stage periprosthetic joint infection with extensor mechanism failure: a retrospective outcome and reinfection rate analysis of a case series.Musculoskeletal surgery · 2025Article
- From image to index: diagnostic accuracy of a novel semi-quantitative approach for assessing suspected periprosthetic joint infection with triple-phase bone scintigraphy.Annals of nuclear medicine · 2025Article
- An overview of the current diagnostic approach to Periprosthetic Joint Infections.Orthopedic reviews · 2024Article
- Early results of a novel modular knee arthrodesis implant after uncontrolled periprosthetic knee joint infection.BMC musculoskeletal disorders · 2023Article
- Preoperative Aspiration Culture (PAC) for the Diagnosis of Infection in a Prosthetic Knee Joint.The archives of bone and joint surgery · 2018Review
- Implant allergy.Allergologie select · 2017Review
- Periprosthetic Joint Infection of Shoulder Arthroplasties: Diagnostic and Treatment Options.BioMed research international · 2017Review
- Emperor's new clothes: Is particle disease really infected particle disease?Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2016Review
- Outcome of total knee replacement following explantation and cemented spacer therapy.GMS Interdisciplinary plastic and reconstructive surgery DGPW · 2016Article
- [Synovial biomarkers for differential diagnosis of painful arthroplasty].Der Orthopade · 2015Article
- [Diagnosis of periprosthetic hip infections].Operative Orthopadie und Traumatologie · 2015Article
- Diagnostic work-up strategy for periprosthetic joint infections after total hip and knee arthroplasty: a 12-year experience on 320 consecutive cases.Patient safety in surgery · 2015Article
- Lipopolysaccharide-binding protein: a valuable biomarker in the differentiation between periprosthetic joint infection and aseptic loosening?International orthopaedics · 2014Article
- Optimal culture incubation time in orthopedic device-associated infections: a retrospective analysis of prolonged 14-day incubation.Journal of clinical microbiology · 2014Article
- Human osteoblast damage after antiseptic treatment.International orthopaedics · 2014Article
- Evaluation of an interdisciplinary therapy algorithm in patients with prosthetic joint infections.International orthopaedics · 2013Article
- [Diagnosis and treatment of periprosthetic infections].Der Unfallchirurg · 2012Article
- High rate of infection control with one-stage revision of septic knee prostheses excluding MRSA and MRSE.Clinical orthopaedics and related research · 2012Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reliable confirmation of periprosthetic infection after total knee arthroplasty is a diagnostic challenge. The present work reviews published data evaluating the available diagnostic tools. Erythrocyte sedimentation rate and C-reactive protein serum levels are relatively sensitive methods with rather low specificity towards periprosthetic infection and are mainly applied to exclude infection. Studies evaluating scintigraphic methods--especially white cell scans--provide inconsistent data with varying accuracy. Consequently, white cell scans cannot be recommended as standard methods. Immunoscintigraphy with antigranulocyte antibodies and FDG-PET scans demonstrated promising results with particularly high sensitivities, but have to be validated in larger studies. Microbiological evaluation of joint aspirates proved high specificity for periprosthetic infection. However, an average of 20% of infected cases remained undetected. Nevertheless, aspiration is widely recommended for preoperative isolation of the infecting organism. Intraoperative frozen sections demonstrated excellent specificity with good sensitivity. The real accuracy of intraoperative culture and permanent histology cannot be determined due to the missing golden standard; however, a combination of both methods is recommended to define the final diagnosis. Large studies validating both methods and criteria for the final diagnosis of periprosthetic infection are necessary to optimize the diagnostic algorithm.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.