ArticleImmunogenetics2006
The salmonid MHC class I: more ancient loci uncovered.
Article in Immunogenetics, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Intra-specific copy number variation of MHC class II genes in the Siamese fighting fish.Immunogenetics · 2022Article
- MHC class I evolution; from Northern pike to salmonids.BMC ecology and evolution · 2021Article
- Review
- Major histocompatibility complex (MHC) fragment numbers alone - in Atlantic cod and in general - do not represent functional variability.F1000Research · 2018Article
- Small-scale intraspecific patterns of adaptive immunogenetic polymorphisms and neutral variation in Lake Superior lake trout.Immunogenetics · 2018Article
- EGAR, A Food Protein-Derived Tetrapeptide, Reduces Seizure Activity in Pentylenetetrazole-Induced Epilepsy Models Through α-Amino-3-Hydroxy-5-Methyl-4-Isoxazole Propionate Receptors.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2017Article
- Evolution of innate-like T cells and their selection by MHC class I-like molecules.Immunogenetics · 2016Review
- MHC and Evolution in Teleosts.Biology · 2016Review
- A comprehensive analysis of teleost MHC class I sequences.BMC evolutionary biology · 2015Article
- Multiple divergent haplotypes express completely distinct sets of class I MHC genes in zebrafish.Immunogenetics · 2014Article
- Evolution by selection, recombination, and gene duplication in MHC class I genes of two Rhacophoridae species.BMC evolutionary biology · 2013Article
- Selection and phylogenetics of salmonid MHC class I: wild brown trout (Salmo trutta) differ from a non-native introduced strain.PloS one · 2013Article
- Signatures of natural selection among lineages and habitats in Oncorhynchus mykiss.Ecology and evolution · 2012Article
- Molecular modeling of class I and II alleles of the major histocompatibility complex in Salmo salar.Journal of computer-aided molecular design · 2010Article
- MHC evolution in three salmonid species: a comparison between class II alpha and beta genes.Immunogenetics · 2010Article
- Article
- Comprehensive analysis of MHC class I genes from the U-, S-, and Z-lineages in Atlantic salmon.BMC genomics · 2010Article
- MH class IIalpha polymorphism in local and global adaptation of Arctic charr (Salvelinus alpinus L.).Immunogenetics · 2008Article
- Multiple expressed MHC class II loci in salmonids; details of one non-classical region in Atlantic salmon (Salmo salar).BMC genomics · 2008Article
- Genomic organization of duplicated major histocompatibility complex class I regions in Atlantic salmon (Salmo salar).BMC genomics · 2007Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An unprecedented level of sequence diversity has been maintained in the salmonid major histocompatibility complex (MHC) class I UBA gene, with between lineage AA sequence identities as low as 34%. The derivation of deep allelic lineages may have occurred through interlocus exon shuffling or convergence of ancient loci with the UBA locus, but until recently, no such ancient loci were uncovered. Herein, we document the existence of eight additional MHC class I loci in salmon (UCA, UDA, UEA, UFA, UGA, UHA, ULA, and ZE), six of which share exon 2 and 3 lineages with UBA, and three of which have not been described elsewhere. Half of the UBA exon 2 lineages and all UBA exon 3 lineages are shared with other loci. Two loci, UGA and UEA, share only a single exon lineage with UBA, likely generated through exon shuffling. Based on sequence homologies, we hypothesize that most exchanges and duplications occurred before or during tetraploidization (50 to 100 Ma). Novel loci that share no relationship with other salmonid loci are also identified (UHA and ZE). Each locus is evaluated for its potential to function as a class Ia gene based on gene expression, conserved residues and polymorphism. UBA is the only locus that can indisputably be classified as a class Ia gene, although three of the eight loci (ZE, UCA, and ULA) conform in three out of four measures. We hypothesize that these additional loci are in varying states of degradation to class Ib genes.
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