ArticleEmergency medicine journal : EMJ2006
The effects of commonly used resuscitation fluids on whole blood coagulation.
Article in Emergency medicine journal : EMJ, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 37 citations in OpenAlex.
- Individualizing Fluid Management in Patients with Acute Respiratory Distress Syndrome and with Reduced Lung Tissue Due to Surgery-A Narrative Review.Journal of personalized medicine · 2023Review
- "COAGULATION": a mnemonic device for treating coagulation disorders following traumatic brain injury-a narrative-based method in the intensive care unit.Frontiers in public health · 2023Article
- 28-day thawed plasma maintains αVox sanguinis · 2021Article
- Intravenous Fluid Administration and the Coagulation System.Frontiers in veterinary science · 2021Review
- Effect of 7.5% hypertonic saline solution on whole blood coagulation in healthy dogs using thromboelastography.Journal of veterinary emergency and critical care (San Antonio, Tex. : 2001) · 2020Article
- Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock.Thrombosis research · 2019Article
- Effects of Dextran-70 and Albumin on Coagulation in Experimental Hemorrhage in the Guinea Pig.Shock (Augusta, Ga.) · 2018Article
- Intravenous synthetic platelet (SynthoPlate) nanoconstructs reduce bleeding and improve 'golden hour' survival in a porcine model of traumatic arterial hemorrhage.Scientific reports · 2018Article
- Cerebral collateral therapeutics in acute ischemic stroke: A randomized preclinical trial of four modulation strategies.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Free oscillation rheometry monitoring of haemodilution and hypothermia and correction with fibrinogen and factor XIII concentrates.Scandinavian journal of trauma, resuscitation and emergency medicine · 2013Article
- In neonates requiring intravascular volume resuscitation is the use of gelofusine safe and efficacious?Archives of disease in childhood · 2007Review
- Impairment of coagulation by commonly used resuscitation fluids in human volunteers.Emergency medicine journal : EMJ · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesEvidence on the effect of crystalloid and colloid resuscitation fluids on coagulation is confusing, with contradictory results from previous studies. This study was performed to test the effect on whole blood coagulation of a range of resuscitation fluids in vitro using a single method at a single dilution.
methodsSeven resuscitation fluids were tested in vitro at a dilution of 40%. Whole blood coagulation was measured using a Sonoclot analyser.
resultsA crystalloid/colloid split of effect on coagulation in vitro was not seen. The time to clot formation with Gelofusine, dextran and hydroxyethyl starch was a greatly increased, whereas saline and Haemaccel had little effect, or were slightly procoagulant.
conclusionsSome resuscitation fluids have a profound effect on coagulation. The confusion in the literature may result from the effect on coagulation being both fluid and dilution dependent, with no simple crystalloid/colloid split.
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Registered trials
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