ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2006
Deficiency of gammadelta T lymphocytes contributes to mortality and immunosuppression in sepsis.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 57 citations in OpenAlex.
- CLEC-1 promotes early IFN response in cDC1s and favors immune dysregulation during sepsis in mice.iScience · 2026Article
- Guardians within: Cross-talk between the gut microbiome and host immune system.World journal of gastrointestinal pathophysiology · 2025Review
- Mechanisms of immune suppression in sepsis/shock: one investigator's/lab group's experience (SLB 2024 legacy award presentation).Journal of leukocyte biology · 2025Article
- VISTA nonredundantly regulates proliferation and CD69low γδ T cell accumulation in the intestine in murine sepsis.Journal of leukocyte biology · 2024Article
- Increased Interleukin-17-Producing γδT Cells in the Brain Exacerbate the Pathogenesis of Sepsis-Associated Encephalopathy and Sepsis-Induced Anxiety in Mice.Journal of clinical medicine · 2023Article
- Increased Vδ1γδT cells predominantly contributed to IL-17 production in the development of adult human post-infectious irritable bowel syndrome.BMC gastroenterology · 2021Article
- Intestinal intraepithelial lymphocytes: Maintainers of intestinal immune tolerance and regulators of intestinal immunity.Journal of leukocyte biology · 2021Review
- Immune Cell Number, Phenotype, and Function in the Elderly with Sepsis.Aging and disease · 2021Review
- Neuronal-Activated ILC2s Promote IL-17A Production in Lung γδ T Cells During Sepsis.Frontiers in immunology · 2021Article
- Pathological alteration and therapeutic implications of sepsis-induced immune cell apoptosis.Cell death & disease · 2019Review
- Shenfu injection prolongs survival and protects the intestinal mucosa in rats with sepsis by modulating immune response.The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology · 2019Article
- Innate T cells in the intensive care unit.Molecular immunology · 2019Review
- Glucocorticoids regulate the proliferation of T cells via miRNA-155 in septic shock.Experimental and therapeutic medicine · 2016Article
- Role of cellular events in the pathophysiology of sepsis.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2016Review
- Differential alterations of tissue T-cell subsets after sepsis.Immunology letters · 2015Article
- Murine IL-17+ Vγ4 T lymphocytes accumulate in the lungs and play a protective role during severe sepsis.BMC immunology · 2015Article
- The P2X7 Receptor Contributes to the Development of the Exacerbated Inflammatory Response Associated with Sepsis.Journal of innate immunity · 2015Article
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- Association of γδ T cells with disease severity and mortality in septic patients.Clinical and vaccine immunology : CVI · 2013Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Studies have indicated that gammadelta T lymphocytes play an important role in the regulation of immune function and the clearance of intracellular pathogens. We have recently reported that intraepithelial lymphocytes (IEL), which are rich in gammadelta T cells, within the small intestine illustrated a significant increase in apoptosis and immune dysfunction in mice subjected to sepsis. However, the contribution of gammadelta T cells to the host response to polymicrobial sepsis remains unclear. In this study, we initially observed that after sepsis induced by cecal ligation and puncture (CLP), there was an increase in small intestinal IEL CD8+gammadelta+ T cells in control gammadelta+/+ mice. Importantly, we subsequently found an increased early mortality in mice lacking gammadelta T cells (gammadelta-/- mice) after sepsis. This was associated with decreases in plasma TNF-alpha, IL-6, and IL-12 levels in gammadelta-/- mice compared with gammadelta+/+ mice after sepsis. In addition, even though in vitro LPS-stimulated peritoneal macrophages showed a reduction in IL-6 and IL-12 release after CLP, these cytokines were less suppressed in macrophages isolated from gammadelta-/- mice. Alternatively, IL-10 release was not different between septic gammadelta+/+ and gammadelta-/- mice. Whereas T helper (Th)1 cytokine release by anti-CD3-stimulated splenocytes was significantly depressed in septic gammadelta+/+ mice, there was no such depression in gammadelta-/- mice. However, gammadelta T cell deficiency had no effect on Th2 cytokine release. These findings suggest that gammadelta T cells may play a critical role in regulating the host immune response and survival to sepsis, in part by alteration of the level of IEL CD8+gammadelta+ T cells and through the development of the Th1 response.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.