Evidence map›Paper›PMID 16793898›Full record

ArticleThe Journal of physiology2006

Arterial oxygenation influences central motor output and exercise performance via effects on peripheral locomotor muscle fatigue in humans.

Markus Amann, Marlowe W Eldridge, Andrew T Lovering, Michael K Stickland, David F Pegelow, Jerome A Dempsey

Registry-linked trialOpen access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of physiology, 2006. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04305873 (Effect of Exercise-induced Hypoxemia on Cytokine and Stress Hormone Responses Among Endurance-trained Athletes), which is not on this map. Cited by 150 papers.

0numbers the graph read from it
0cells of the map it votes in
150citing papers in PubMed
64.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04305873 unknown statusnot on this mapstarted 2020, after this paper: background citation

Effect of Exercise-induced Hypoxemia on Cytokine and Stress Hormone Responses Among Endurance-trained Athletes

TypeobservationalSponsorGepner YftachRan2020 to 2024Enrolled50ConditionsExercise-induced Arterial Hypoxemia
3 · Its place in the literature

Who cites it

150 citing papers in PubMed, 381 citations in OpenAlex.

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  17. Rapidity of responding to a hypoxic challenge during exercise.European journal of applied physiology · 2009
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90 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Markus AmannThe John Rankin Laboratory of Pulmonary Medicine, 4245 Medical Science Center, 1300 University Avenue, Madison, WI 53706, USA. amann@wisc.edu
Marlowe W Eldridge
Andrew T Lovering
Michael K Stickland
David F Pegelow
Jerome A Dempsey
University of Wisconsin–Madison · US

Funding

Respiratory NeurobiologyT32HL007654 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI MITCHELL, GORDON S. · 1987 to 2011
$4.0M
HUMAN VENTILATORY ADAPTIONR01HL015469 · NHLBI · UNIVERSITY OF WISCONSIN-MADISON · PI DEMPSEY, JEROME A · 1985 to 2011
$3.7M
NHLBI NIH HHS R01 HL015469NHLBI NIH HHS R01 HL-15469NHLBI NIH HHS T32 HL007654NHLBI NIH HHS T32 HL-07654
6 · The paper itself

Abstract

Changing arterial oxygen content (C(aO(2))) has a highly sensitive influence on the rate of peripheral locomotor muscle fatigue development. We examined the effects of C(aO(2)) on exercise performance and its interaction with peripheral quadriceps fatigue. Eight trained males performed four 5 km cycling time trials (power output voluntarily adjustable) at four levels of C(aO(2)) (17.6-24.4 ml O(2) dl(-1)), induced by variations in inspired O(2) fraction (0.15-1.0). Peripheral quadriceps fatigue was assessed via changes in force output pre- versus post-exercise in response to supra-maximal magnetic femoral nerve stimulation (DeltaQ(tw); 1-100 Hz). Central neural drive during the time trials was estimated via quadriceps electromyogram. Increased C(aO(2)) from hypoxia to hyperoxia resulted in parallel increases in central neural output (43%) and power output (30%) during cycling and improved time trial performance (12%); however, the magnitude of DeltaQ(tw) (-33 to -35%) induced by the exercise was not different among the four time trials (P > 0.2). These effects of C(aO(2)) on time trial performance and DeltaQ(tw) were reproducible (coefficient of variation = 1-6%) over repeated trials at each F(IO(2)) on separate days. In the same subjects, changing C(aO(2)) also affected performance time to exhaustion at a fixed work rate, but similarly there was no effect of Delta C(aO(2)) on peripheral fatigue. Based on these results, we hypothesize that the effect of C(aO(2)) on locomotor muscle power output and exercise performance time is determined to a significant extent by the regulation of central motor output to the working muscle in order that peripheral muscle fatigue does not exceed a critical threshold.

Indexed as

LocomotionMuscle FatigueAdultElectromyographyHumansHyperoxiaHypoxiaLactic AcidMaleMotor CortexMotor NeuronsMuscle ContractionMuscle, SkeletalOxygenOxygen ConsumptionPhysical EnduranceLactic AcidOxygen

Identifiers

PMID16793898
PMCPMC1995675
OpenAlexW1546019921

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.